Τίτλος:
Antimicrobial activity of copper surfaces against
carbapenemase-producing contemporary Gram-negative clinical isolates
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives: The antimicrobial activity of copper surfaces against a
variety of contemporary carbapenemase-producing Gram-negative bacteria
representative of the most problematic nosocomial pathogens worldwide
was evaluated.
Methods: Twenty-four clinical isolates, comprising four of Escherichia
coli, two of Enterobacter spp., eight of Klebsiella pneumoniae and five
each of Pseudomonas aeruginosa and Acinetobacter baumannii producing
either VIM-1 and/or KPC-2 or VIM-2 or OXA-type carbapenemases, were
studied. The antimicrobial activity of 99% copper (Cu99%) and a 63%
alloy (Cu63%) was evaluated in comparison with that of stainless steel
(SS) and polyvinylchloride (PVC) by incubating similar to 10(6)
cfu/cm(2) of the tested strains on each surface at room temperature.
Results: Copper demonstrated antimicrobial activity against all studied
isolates. This effect was observed earlier and was more pronounced for
Cu99% than for Cu63%. Cu99% showed a bactericidal effect after <2 h
for A. baumannii, 3 h for Enterobacter spp., 5 h for K. pneumoniae and 6
h for P. aeruginosa and E. coli. No viable colonies were recovered from
five (20.8%) isolates after 3 h and from nine (37.5%) isolates after 5
h of incubation on Cu99%.
Conclusions: Copper has significant antimicrobial activity against
multidrug-resistant nosocomial Gram-negative pathogens. This supports
the hypothesis that replacement of high-contact materials with copper
could reduce the high burden of environmental contamination around
high-risk patients. However, this strategy should be seen as an
adjunctive measure to established cleaning protocols and to good hygiene
practices for prevention of hospital-acquired infections.
Συγγραφείς:
Souli, Maria
Galani, Irene
Plachouras, Diamantis
Panagea,
Theofano
Armaganidis, Apostolos
Petrikkos, George and
Giamarellou, Helen
Περιοδικό:
The Journal of antimicrobial chemotherapy
Εκδότης:
Oxford University Press
Λέξεις-κλειδιά:
multidrug resistant; K. pneumoniae; P. aeruginosa; Acinetobacter;
Enterobacter spp.
