Τίτλος:
Childhood leukemia and lymphoma: time trends and factors affecting
survival in five Southern and Eastern European Cancer Registries
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Within Europe, incidence and mortality rates of childhood leukemia and
lymphoma are rather heterogeneous. The present study comprising data
from five Southern and Eastern European Cancer Registries aims to
compare time trends and examine whether sociodemographic variables,
clinical parameters, and proxies of efficient care affect survival.
Data spanning 1996-2010 were obtained for a total of 3,041 newly
diagnosed childhood leukemia and 1,183 lymphoma cases reported by the
Greek Nationwide Registry for Childhood Hematological Malignancies,
Bulgarian National Cancer Registry, Moscow Region and Turkey (Antalya
and Izmir) Cancer Registries. Poisson modeling for the evaluation of
time trends and multivariate Cox regression analysis for the assessment
of prognostic factors were performed.
The incidence of leukemia was increasing in all cases, with Bulgaria and
Greece presenting statistically significant annual changes (+3.5, and
+1.7 %, respectively), followed by marginally increasing trends in
Izmir and Moscow; by contrast, there was a remarkable, statistically
significant, decreasing mortality trend for leukemia. Rates for lymphoma
remained flat. Greece experienced almost twofold better survival rates
for both leukemia and lymphoma, probably due to its higher socioeconomic
status during the study period. Overall, patients with leukemia living
in rural areas had a 28 % lower prognosis (RR: 1.28, 95 % CI
1.03-1.59), pointing to effects of remoteness, when the most privileged
country (Greece) was excluded from the analysis.
The favorable mortality trends highlight the progress in
Southern-Eastern European countries along their trajectory to converge
with Northern-Western EU counterpart states. Socioeconomic status may
act as a multipotent factor underlying the study findings.
Συγγραφείς:
Petridou, Eleni Th
Dimitrova, Nadya
Eser, Sultan
Kachanov,
Denis
Karakilinc, Hulya
Varfolomeeva, Svetlana
Belechri,
Maria
Baka, Margarita
Moschovi, Maria
Polychronopoulou,
Sofia
Athanasiadou-Piperopoulou, Fani
Fragandrea, Ioanna and
Stiakaki, Eftichia
Pourtsidis, Apostolos
Stefanadis,
Christodoulos
Coebergh, Jan-Willem
Sergentanis, Theodoros N.
Περιοδικό:
Cancer Causes and Control
Λέξεις-κλειδιά:
Childhood leukemia; Childhood lymphoma; Survival; Incidence; Mortality;
Time trends; Socioeconomic status
DOI:
10.1007/s10552-013-0188-y
