Περίληψη:
Background Psoriasis is associated with a variety of comorbidities such
as obesity and cardiovascular disease. Objective In a cross-sectional
study, we explored whether obstructive sleep apnea and hypopnea syndrome
(OSAHS) is associated with psoriasis characteristics and metabolic
parameters. Methods Thirty-five patients with chronic plaque psoriasis
underwent a nocturnal polysomnography study and were analysed for
Apnoea-Hypopnoea Index to assess OSAHS severity and Framigham score to
predict the absolute risk of coronary artery disease at 10years. The
association of OSAHS with psoriasis was examined according to psoriasis
characteristics (PASI and DLQI scores, disease duration and previous use
of systemic treatments), metabolic parameters (Body Mass Index - BMI,
waist to hip ratio - WHR, lipid profile) and other comorbidities
(obesity, hypertension, arthritis and cardiovascular disease). Results
There was no correlation between psoriasis characteristics and OSAHS.
Psoriasis patients with OSAHS presented more frequent snoring and lower
sleep quality compared with those without OSAHS. In univariate analyses,
OSAHS was associated with increased BMI and hypertension in psoriasis
patients. In multivariable logistic regression models, there was
statistically significant evidence that only BMI and hypertension were
associated with increased risk of OSAHS, adjusting for psoriasis
characteristics, age and gender. Presence of metabolic syndrome, WHR,
and smoking were not significant risk factors for OSAHS. In subgroup
analyses, OSAHS correlated with duration of psoriasis (>8years) in women
(P=0.021) and with Framigham score in men (P=0.035). Conclusion OSAHS
may be a comorbidity in obese psoriasis patients with hypertension.
Treatment with continuous positive airway pressure and weight loss
interventions should be initiated.
Συγγραφείς:
Papadavid, E.
Vlami, K.
Dalamaga, M.
Giatrakou, S. and
Theodoropoulos, K.
Gyftopoulos, S.
Stavrianeas, N.
Papiris,
S.
Rigopoulos, D.
