Τίτλος:
Placental growth factor (PlGF): a key to optimizing fetal growth
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The needs of the uterus and the fetus for the provision of nutrients and
oxygen, supplied by the blood flow, are understandably extremely high,
with the circulatory system playing the most important role in this
action. Abnormal vascular growth and transformation that create a high
vessel resistance network have been associated with various pregnancy
pathologies, including miscarriage, small for gestational age (SGA)
fetuses with or without preeclampsia and intrauterine growth restriction
(IUGR). Placental growth factor (PlGF) has a major role in
vasculogenesis and angiogenesis in human placenta. Low concentrations of
PlGF and high concentrations of its inhibitor-soluble Fms-like tyrosine
kinase-1 (sFlt-1) are linked with impaired angiogenesis and placental
development, leading to the above pregnancy complications. The activity
of vascular endothelial growth factor (VEGF), which is the most potent
of all angiogenic mediators, is partly modulated by PlGF. Although the
mechanisms via which PlGF exerts its various effects are still under
investigation, we herein discuss the known actions exerted by this major
mediator together with its results on fetal growth.
Συγγραφείς:
Vrachnis, Nikolaos
Kalampokas, Emmanouil
Sifakis, Stavros and
Vitoratos, Nikolaos
Kalampokas, Theodoros
Botsis, Demetrios and
Iliodromiti, Zoe
Περιοδικό:
Journal of Maternal-Fetal and Neonatal Medicine
Εκδότης:
TAYLOR & FRANCIS LTD LONDON
Λέξεις-κλειδιά:
Angiogenesis; fetal growth; Fms-like tyrosine kinase-1; kinase-inserted
domain receptor; placental growth factor; vascular endothelial growth
factor
DOI:
10.3109/14767058.2013.766694
