Περίληψη:
Since its discovery as an adipocyte-secreted hormone, leptin has been
found to impact food intake, energy homeostasis, and metabolism through
its effects on the central nervous system and peripheral organs. Recent
research indicates that leptin may also be involved in cognition, immune
function, and bone metabolism. These findings place leptin at the
intersection of neuroendocrinology and metabolism, and possibly immune
function, and render it an appealing therapeutic target for several
niche areas of unmet clinical need. Current evidence regarding classic
and emerging roles of leptin as well as the pros and cons of its
potential clinical use are summarized herein.
Συγγραφείς:
Dalamaga, Maria
Chou, Sharon H.
Shields, Kelsey and
Papageorgiou, Panagiotis
Polyzos, Stergios A.
Mantzoros,
Christos S.
