Τίτλος:
Resistin in mid-trimester amniotic fluid in trisomy 21
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: The aim of this study was to examine whether resistin is
present in second trimester amniotic fluid from trisomy 21 (also known
as Down’s syndrome) pregnancies and whether its concentration differs
compared with euploid pregnancies.
Methods: The study cohort consisted of 58 women in the mid-trimester of
pregnancy who underwent amniocentesis for prenatal diagnosis, 31 of whom
carried a single fetus with diagnosed trisomy 21 (study group) and the
rest with normal karyotype (control group, n = 27). Groups were matched
for maternal and gestational age. Levels of resistin in amniotic fluid
were measured by a commercially available enzyme-linked immunosorbent
assay (ELISA) kit.
Results: Resistin was detected in all amniotic fluid samples. Its median
concentration in the second trimester amniotic fluid of trisomy 21
pregnancies (2.1 ng/ml) was statistically significantly lower (p value
<0.001) in comparison with that in euploid pregnancies (3.3 ng/ml).
Conclusions: Resistin is a physiologic constituent of second trimester
amniotic fluid. Lower levels of amniotic fluid resistin in pregnancies
with trisomy 21 may reflect altered metabolic pathways in utero that
could possibly be related with phenotypic features of the syndrome.
Συγγραφείς:
Vrachnis, N.
Gkogkas, L.
Iliodromiti, S.
Grigoriadis, C. and
Samoli, E.
Iliodromiti, Z.
Pangalos, C.
Pappa, K. I. and
Drakoulis, N.
Creatsas, G.
Botsis, D.
Περιοδικό:
Journal of Maternal-Fetal and Neonatal Medicine
Εκδότης:
TAYLOR & FRANCIS LTD LONDON
Λέξεις-κλειδιά:
Amniotic fluid; cytokines; Down’s syndrome; resistin; trisomy 21
DOI:
10.3109/14767058.2013.789848
