Περίληψη:
BACKGROUND & AIMS: Few modifiable risk factors have been implicated in
the etiology of pancreatic cancer. There is little evidence for the
effects of caffeinated coffee, decaffeinated coffee, or tea intake on
risk of pancreatic cancer. We investigated the association of total
coffee, caffeinated coffee, decaffeinated coffee, and tea consumption
with risk of pancreatic cancer.
METHODS: This study was conducted within the European Prospective
Investigation into Nutrition and Cancer cohort, comprising male and
female participants from 10 European countries. Between 1992 and 2000,
there were 477,312 participants without cancer who completed a dietary
questionnaire and were followed up to determine pancreatic cancer
incidence. Coffee and tea intake was calibrated with a 24-hour dietary
recall. Adjusted hazard ratios (HRs) were computed using multivariable
Cox regression.
RESULTS: During a mean follow-up period of 11.6 y, 865 first incidences
of pancreatic cancers were reported. When divided into fourths, neither
total intake of coffee (HR, 1.03; 95% confidence interval [CI],
0.83-1.27; high vs low intake), decaffeinated coffee ( HR, 1.12; 95%
CI, 0.76-1.63; high vs low intake), nor tea were associated with risk of
pancreatic cancer ( HR, 1.22, 95% CI, 0.95-1.56; high vs low intake).
Moderately low intake of caffeinated coffee was associated with an
increased risk of pancreatic cancer ( HR, 1.33; 95% CI, 1.02-1.74),
compared with low intake. However, no graded dose response was observed,
and the association attenuated after restriction to histologically
confirmed pancreatic cancers.
CONCLUSIONS: Based on an analysis of data from the European Prospective
Investigation into Nutrition and Cancer cohort, total coffee,
decaffeinated coffee, and tea consumption are not related to the risk of
pancreatic cancer.
Συγγραφείς:
Bhoo-Pathy, Nirmala
Uiterwaal, Cuno S. P. M.
Dik, Vincent K. and
Jeurnink, Suzanne M.
Bech, Bodil H.
Overvad, Kim
Halkjaer,
Jytte
Tjonneland, Anne
Boutron-Ruault, Marie-Christine and
Fagherazzi, Guy
Racine, Antoine
Katzke, Verena A.
Li,
Kuanrong
Boeing, Heiner
Floegel, Anna
Androulidaki, Anna and
Bamia, Christina
Trichopoulou, Antonia
Masala, Giovanna and
Panico, Salvatore
Crosignani, Paolo
Tumino, Rosario
Vineis,
Paolo
Peeters, Petra H. M.
Gavrilyuk, Oxana
Skeie, Guri and
Weiderpass, Elisabete
Duell, Eric J.
Arguelles, Marcial and
Molina-Montes, Esther
Navarro, Carmen
Ardanaz, Eva and
Dorronsoro, Miren
Lindkvist, Bjorn
Wallstrom, Peter
Sund,
Malin
Ye, Weimin
Khaw, Kay-Tee
Wareham, Nick
Key,
Timothy J.
Travis, Ruth C.
Duarte-Salles, Talita
Freisling,
Heinz
Licaj, Idlir
Gallo, Valentina
Michaud, Dominique S.
and Riboli, Elio
Bueno-De-Mesquita, H. Bas
