Περίληψη:
Increased physical activity (PA) is associated with a reduced risk of
several cancers. PA may reduce cancer risk by changing endogenous
hormones levels, but relatively little research has focused on this
topic. The purpose of this study was to elucidate the relation between
PA and endogenous hormone concentrations.
A cross-sectional analysis of 798 pre- and 1,360 post-menopausal women
included as controls in case-control studies on endogenous hormones
(steroids, progesterone, sex-hormone-binding globulin (SHBG), and growth
factors) levels, and cancer risk nested within European Prospective
Investigation into Cancer and Nutrition cohort was performed.
Multivariate regression analyses were performed to compare geometric
mean levels of hormones and SHBG by categories of PA.
In pre-menopausal women, active women had 19 % significantly lower
concentrations of androstenedione, 14 % lower testosterone, and 20 %
lower free testosterone than inactive women, while no differences were
observed for estrogens, progesterone, SHBG, and growth factors. In
post-menopausal women, active women had 18 % significantly lower
estradiol and 20 % lower free estradiol concentrations than inactive
women, while no differences were observed for the other hormones and
SHBG. More vigorous forms of physical activity were associated with
higher insulin-like growth factor-I concentrations. Adjustment for body
mass index did not alter the associations. Overall, the percentage of
variance in hormone concentrations explained by PA levels was < 2 %.
Our results support the hypothesis of an influence, although small in
magnitude, of PA on sex hormone levels in blood, independent of body
size.
Συγγραφείς:
Rinaldi, S.
Kaaks, R.
Friedenreich, C. M.
Key, T. J. and
Travis, R.
Biessy, C.
Slimani, N.
Overvad, K. and
Ostergaard, J. N.
Tjonneland, A.
Olsen, A.
Mesrine, S. and
Fournier, A.
Dossus, L.
Lukanova, A.
Johnson, T.
Boeing,
H.
Vigl, M.
Trichopoulou, A.
Benetou, V.
Trichopoulos,
D.
Masala, G.
Krogh, V.
Tumino, R.
Ricceri, F. and
Panico, S.
Bueno-de-Mesquita, H. B.
Monninkhof, E. M.
May,
A. M.
Weiderpass, E.
Quiros, J. R.
Travier, N. and
Molina-Montes, E.
Amiano, P.
Huerta, J. M.
Ardanaz, E. and
Sund, M.
Johansson, M.
Khaw, K. T.
Wareham, N.
Scalbert,
A.
Gunter, M. J.
Riboli, E.
Romieu, I.
