Περίληψη:
Background Few studies have investigated the association between
whole-grain intake and colorectal cancer. Because whole-grain intake
estimation might be prone to measurement errors, more objective measures
(eg, biomarkers) could assist in investigating such associations.
Methods The association between alkylresorcinols, biomarkers of
whole-grain rye and wheat intake, and colorectal cancer incidence were
investigated using prediagnostic plasma samples from colorectal cancer
case patients and matched control subjects nested within the European
Prospective Investigation into Cancer and Nutrition. We included 1372
incident colorectal cancer case patients and 1372 individual matched
control subjects and calculated the incidence rate ratios (IRRs) for
overall and anatomical subsites of colorectal cancer using conditional
logistic regression adjusted for potential confounders. Regional
differences (Scandinavia, the Mediterranean, Central Europe) were also
explored.
Results High plasma total alkylresorcinol concentration was associated
with lower incidence of distal colon cancer; the adjusted incidence rate
ratio of distal colon cancer for the highest vs lowest quartile of
plasma total alkylresorcinols was 0.48 (95% confidence interval [CI]
= 0.28 to 0.83). An inverse association between plasma total
alkylresorcinol concentrations and colon cancer was found for
Scandinavian participants (IRR per doubling = 0.83; 95% CI = 0.70 to
0.98). However, plasma total alkylresorcinol concentrations were not
associated with overall colorectal cancer, proximal colon cancer, or
rectal cancer. Plasma alkylresorcinols concentrations were associated
with colon and distal colon cancer only in Central Europe and
Scandinavia (ie, areas where alkylresorcinol levels were higher).
Conclusions High concentrations of plasma alkylresorcinols were
associated with a lower incidence of distal colon cancer but not with
overall colorectal cancer, proximal colon cancer, and rectal cancer.
Συγγραφείς:
Kyro, Cecilie
Olsen, Anja
Landberg, Rikard
Skeie, Guri and
Loft, Steffen
Aman, Per
Leenders, Max
Dik, Vincent K. and
Siersema, Peter D.
Pischon, Tobias
Christensen, Jane and
Overvad, Kim
Boutron-Ruault, Marie-Christine
Fagherazzi, Guy and
Cottet, Vanessa
Kuehn, Tilman
Chang-Claude, Jenny
Boeing,
Heiner
Trichopoulou, Antonia
Bamia, Christina
Trichopoulos,
Dimitrios
Palli, Domenico
Krogh, Vittorio
Tumino, Rosario
and Vineis, Paolo
Panico, Salvatore
Peeters, Petra H. and
Weiderpass, Elisabete
Bakken, Toril
Asli, Lene Angell and
Argueelles, Marcial
Jakszyn, Paula
Sanchez, Maria-Jose and
Amiano, Pilar
Huerta, Jose Maria
Barricarte, Aurelio and
Ljuslinder, Ingrid
Palmqvist, Richard
Khaw, Kay-Tee
Wareham,
Nick
Key, Timothy J.
Travis, Ruth C.
Ferrari, Pietro and
Freisling, Heinz
Jenab, Mazda
Gunter, Marc J.
Murphy, Neil
and Riboli, Eilo
Tjonneland, Anne
Bueno-de-Mesquita, H. B(as)
