Τίτλος:
Age-dependent association of serum prolactin with glycaemia and insulin
sensitivity in humans
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The dopamine agonist bromocriptine has been approved for the treatment
of type 2 diabetes in the United States. Bromocriptine inhibits
prolactin secretion, and patients with hyperprolactinaemia display
impaired insulin sensitivity. We therefore hypothesized that low
prolactin levels are associated with lower glycaemia and higher insulin
sensitivity in healthy subjects. Prolactin levels were determined from
fasting serum in participants without diabetes from the cross-sectional
Tubingen family study for type 2 diabetes (m/f = 562/1,121, age = 40 +/-
A 13 years, BMI = 30 +/- A 9 kg/m(2)). A 75 g oral glucose tolerance
test was performed, and the area under the glucose curve
(AUC(0-120)Glucose) and insulin sensitivity index were calculated. A
subgroup (n = 494) underwent hyperinsulinaemic-euglycaemic clamp tests.
Prolactin associated positively with insulin sensitivity (p = 0.001,
adjusted for gender, age, and BMI). Age strongly interacted (p < 0.0001)
with the effect of prolactin on insulin sensitivity, inverting the
positive relationship to a negative one in younger participants.
Glycated haemoglobin (HbA1c) and AUC(0-120)Glucose correlated negatively
with prolactin, and an interaction with age was found as well. Higher
prolactin levels are associated with improved insulin sensitivity and
lower glucose in individuals without diabetes. This relationship turns
to its opposite in younger persons. As prolactin is a proxy for the
dopaminergic tone in the central nervous system, these associations may
indicate an age-dependent influence of the brain on peripheral insulin
sensitivity.
Συγγραφείς:
Wagner, R.
Heni, M.
Linder, K.
Ketterer, C.
Peter, A.
and Boehm, A.
Hatziagelaki, E.
Stefan, N.
Staiger, H. and
Haering, H. -U.
Fritsche, A.
Περιοδικό:
ACTA DIABETOLOGICA LATINA
Εκδότης:
SPRINGER-VERLAG ITALIA SRL
Λέξεις-κλειδιά:
Prolactin; Insulin sensitivity; Bromocriptine; Cross-sectional
investigation; Interaction with age
DOI:
10.1007/s00592-013-0493-7
