Περίληψη:
Introduction: Adipose tissue secretes numerous bioactive peptides,
collectively termed “adipocytokines” or “adipokines”. Adipokines
act in a paracrine, autocrine, or endocrine manner and regulate several
physiological and pathological processes. Increasing evidence indicates
that adipokines are implicated also in several malignancies, including
lung cancer as well.
Aim: The aim of this study is to summarize data concerning adipokines in
lung cancer pathogenesis, prognosis and survival; the role of adipokines
in lung cancer cachexia is also examined.
Materials and Methods: A systematic literature search was performed in
the electronic database of Medline. Several studies and review articles
met the inclusion criteria.
Results: Leptin and adiponectin are the best studied adipokines. The
majority of the relevant studies has investigated the potential
correlations mainly between leptin, adiponectin, and sometimes also
resistin, and nutritional status, systemic inflammation of lung cancer
or lung cancer cachexia and have also assessed their prognostic
significance. Few other studies have studied genetic variations in
leptin, leptin receptor and adiponectin genes and their association with
lung cancer susceptibility and prognosis. The ongoing list of adipokines
associated with lung cancer also includes resistin, chemerin, and
visfatin.
Conclusions: Increasing evidence points to the involvement of certain
adipocytokines in lung cancer development, progression and prognosis. No
conclusive evidence exists so far with regards to the role of
adipocytokines in lung cancer cachexia. Future, longitudinal studies are
warranted in order to clarify the role of adipocytokines in lung cancer
and also uncover adipocytokines as novel therapeutic targets. (C) 2013
Elsevier Ltd. All rights reserved.
Συγγραφείς:
Ntikoudi, E.
Kiagia, M.
Boura, P.
Syrigos, K. N.
