Ερευνητικό υλικό ΕΚΠΑ

Genome-wide association study identifies multiple loci associated with
bladder cancer risk

Αγγλικά

Candidate gene and genome-wide association studies (GWAS) have
identified 11 independent susceptibility loci associated with bladder
cancer risk. To discover additional risk variants, we conducted a new
GWAS of 2422 bladder cancer cases and 5751 controls, followed by a
meta-analysis with two independently published bladder cancer GWAS,
resulting in a combined analysis of 6911 cases and 11 814 controls of
European descent. TaqMan genotyping of 13 promising single nucleotide
polymorphisms with P < 1 x 10(-5) was pursued in a follow-up set of 801
cases and 1307 controls. Two new loci achieved genome-wide statistical
significance: rs10936599 on 3q26.2 (P = 4.53 x 10(-9)) and rs907611 on
11p15.5 (P = 4.11 x 10(-8)). Two notable loci were also identified that
approached genome-wide statistical significance: rs6104690 on 20p12.2 (P
= 7.13 x 10(-7)) and rs4510656 on 6p22.3 (P = 6.98 x 10(-7)); these
require further studies for confirmation. In conclusion, our study has
identified new susceptibility alleles for bladder cancer risk that
require fine-mapping and laboratory investigation, which could further
understanding into the biological underpinnings of bladder
carcinogenesis.

2014

Figueroa, Jonine D.
Ye, Yuanqing
Siddiq, Afshan and
Garcia-Closas, Montserrat
Chatterjee, Nilanjan
Prokunina-Olsson,
Ludmila
Cortessis, Victoria K.
Kooperberg, Charles
Cussenot,
Olivier
Benhamou, Simone
Prescott, Jennifer
Porru, Stefano
and Dinney, Colin P.
Malats, Nuria
Baris, Dalsu
Purdue, Mark
and Jacobs, Eric J.
Albanes, Demetrius
Wang, Zhaoming
Deng,
Xiang
Chung, Charles C.
Tang, Wei
Bueno-De-Mesquita, H. Bas
and Trichopoulos, Dimitrios
Ljungberg, Borje
Clavel-Chapelon,
Frangoise
Weiderpass, Elisabete
Krogh, Vittorio
Dorronsoro,
Miren
Travis, Ruth
Tjonneland, Anne
Brenan, Paul and
Chang-Claude, Jenny
Riboli, Elio
Conti, David and
Gago-Dominguez, Manuela
Stern, Mariana C.
Pike, Malcolm C. and
Van den Berg, David
Yuan, Jian-Min
Hohensee, Chancellor and
Rodabough, Rebecca
Cancel-Tassin, Geraldine
Roupret, Morgan and
Comperat, Eva
Chen, Constance
De Vivo, Immaculata and
Giovannucci, Edward
Hunter, David J.
Kraft, Peter
Lindstrom,
Sara
Carta, Angela
Pavanello, Sofia
Arici, Cecilia and
Mastrangelo, Giuseppe
Kamat, Ashish M.
Lerner, Seth P. and
Grossman, H. Barton
Lin, Jie
Gu, Jian
Pu, Xia and
Hutchinson, Amy
Burdette, Laurie
Wheeler, William
Kogevinas,
Manolis
Tardon, Adonina
Serra, Consol
Carrato, Alfredo and
Garcia-Closas, Reina
Lloreta, Josep
Schwenn, Molly
Karagas,
Margaret R.
Johnson, Alison
Schned, Alan
Armenti, Karla R.
and Hosain, G. M.
Andriole, Jr., Gerald
Grubb, III, Robert and
Black, Amanda
Diver, W. Ryan
Gapstur, Susan M.
Weinstein,
Stephanie J.
Virtamo, Jarmo
Haiman, Chris A.
Landi, Maria T.
and Caporaso, Neil
Fraumeni, Jr., Joseph F.
Vineis, Paolo and
Wu, Xifeng
Silverman, Debra T.
Chanock, Stephen
Rothman,
Nathaniel

Human Molecular Genetics

Oxford University Press

23

5

1387-1398

https://doi.org/10.1093/hmg/ddt519

10.1093/hmg/ddt519

https://pergamos.lib.uoa.gr/uoa/dl/object/3161019