Τίτλος:
In vivo transmission of a plasmid containing the KPC-2 gene in a single
patient
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Here we describe a case of in vivo horizontal interspecies transmission
of a KPC-2-producing plasmid from a Klebsiella pneumoniae to an
Enterobacter aerogenes strain in the same patient. The patient’s gut
flora initially contained a carbapenem-susceptible Enterobacter
aerogenes strain and 10 days after admission a KPC-2-positive Klebsiella
pneumoniae. Three months after admission, a KPC-2-positive Enterobacter
aerogenes was identified in fecal surveillance cultures. This isolate
was isogenic with the initial Enterobacter aerogenes and contained a
KPC-2-coding plasmid identical to that of the Klebsiella pneumoniae. The
patient developed bacteraemia by the KPC-2-positive Klebsiella
pneumoniae 17 days after her first colonization. In vivo horizontal
transmission of bla(KPC)-carrying plasmids between bacterial species
underscores the importance of antibiotic stewardship along with
implementation of infection control measures for the containment of
KPC-producers. (C) 2013 International Society for Chemotherapy of
Infection and Cancer. Published by Elsevier Ltd. All rights reserved.
Συγγραφείς:
Galani, Irene
Panagea, Theofano
Chryssouli, Zoi
Giamarellou,
Helen
Souli, Maria
Περιοδικό:
Journal of Global Antimicrobial Resistance
Εκδότης:
Elsevier Sci Ltd, Exeter, United Kingdom
Λέξεις-κλειδιά:
Enterobacter aerogenes; KPC; Plasmid; Transferable; Conjugation;
Carbapenemases
DOI:
10.1016/j.jgar.2013.02.003
