Τίτλος:
Do estrogen receptor alpha polymorphisms have any impact on the outcome
in an ART program?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
To investigate two of the most studied estrogen receptor alpha
polymorphisms (PvuII and XbaI) in combination, in order to evaluate
their impact on an ART program outcome.
203 normally ovulating women who underwent IVF or ICSI treatment were
genotyped for PvuII and XbaI polymorphisms in ESR1 intron 1 using
Real-Time PCR. The relationship between the presence of polymorphic
alleles and the ovulation induction parameters and outcome was examined.
Women were grouped according to the number of polymorphic alleles they
carried in two groups (0-2 versus 3-4 polymorphic alleles). The presence
of 3 or more polymorphic alleles was associated with significantly lower
E2 levels on the day of hCG administration and a significantly lower
rate of good quality embryos.
There is an association between ESR1 polymorphisms and some ART
parameters such as the level of E2 on the day of hCG administration and
the quality of the embryos. These results underline the importance of
ESR1 as a candidate gene for the prediction of ovarian response to
IVF/ICSI protocols. Future research work concerning several more genes
is necessary for a better evaluation of patients before entering an
IVF/ICSI program.
Συγγραφείς:
Anagnostou, Elli
Malamas, Fotodotis
Mavrogianni, Despina and
Dinopoulou, Vasiliki
Drakakis, Peter
Kallianidis, Konstantinos
and Loutradis, Dimitris
Περιοδικό:
Journal of Assisted Reproduction and Genetics
Εκδότης:
SPRINGER/PLENUM PUBLISHERS
Λέξεις-κλειδιά:
Estrogen receptor alpha; ESR1 gene polymorphisms; PvuII; XbaI; IVF;
ICSI; Estradiol; Embryo quality
DOI:
10.1007/s10815-013-9971-7
