Περίληψη:
The role of systemic risk factors (age, smoking, diabetes, arterial
hypertension) in the development of retinal vein occlusion (RVO) is well
established. However, the association of RVO with genetic predisposition
to thrombosis remains poorly understood. The aim of the study was to
assess any possible additional effect of genetic predisposition to the
already well known ‘classical’ risk factors of RVO in a cohort of
elderly Greek patients. Fifty-one elderly patients with RVO and 51
healthy individuals matched for age and sex were evaluated for systemic
risk factors (smoking, diabetes, dyslipidemia, arterial hypertension)
and coagulation defects (lupus anticoagulant, natural inhibitors of
coagulation). Additionally, genotyping was performed for
mutations/polymorphisms involved in haemostasis such as: FV G1691A, FV
G4070A, FIIG 20210A, MTHFR C677T and A1298C, PAI-1-675 4G/5G, F XIII
exon 2G/T, EPCR A4600G and G4678C. We identified systemic risk factors
in the majority of the patients Hypertension (P=0.001), dyslipidemia
(P=0.029) and diabetes (P=0.01) are associated with RVO in the majority
of the patients. The prevalence of prothrombotic risk factors was not
significantly different in the patients with RVO compared to controls.
Apart from systemic risk factors, genetic predisposition to thrombosis
does not seem to have an important association with RVO in this group of
elderly patients. Blood Coagul Fibrinolysis 24:279-283 (C) 2013 Wolters
Kluwer Health vertical bar Lippincott Williams & Wilkins.
Συγγραφείς:
Giannaki, Kassiani
Politou, Marianna
Rouvas, Alexandros and
Merkouri, Efrossyni
Travlou, Anthi
Theodosiadis, Panayiotis and
Gialeraki, Argyri
