Περίληψη:
The relation between dietary acrylamide intake and esophageal cancer
(EC) risk, including esophageal adenocarcinoma (EAC) and esophageal
squamous cell carcinoma (ESCC), has not been consistent. We evaluated
the association between dietary acrylamide intake and EAC, ESCC, and
overall EC in the European Prospective Investigation into Cancer and
Nutrition (EPIC) cohort.
Multivariate Cox proportional hazards models were used to estimate the
HR and 95 % confidence interval (95 % CI). Since nonlinear relations
were observed, HRs were displayed for quartiles of acrylamide intake in
mu g per day.
After a mean follow-up of 11 years, 341 EC were identified, 142 of which
were EAC, 176 ESCC, and 23 other histological types or not specified. An
increase in EC risk was observed in the second and third quartiles
(HRQ2vsQ1 1.75, 95 % CI 1.12-2.74; HRQ3vsQ1 1.66, 95 % CI 1.05-2.61),
but not in the fourth quartile, and there was no evidence for a linear
dose-response trend. HRs were similarly elevated but not statistically
significant when ESCC and EAC were analyzed separately, due to the small
number of cases observed. No associations were observed when quartiles
were based on energy-adjusted acrylamide intake.
In the EPIC cohort, an association between estimated dietary acrylamide
intake and an increased risk of developing EC was observed in the middle
quartiles but not in the highest quartile; however, results from other
larger cohorts or consortia, and results from biomarker studies, might
add to the evidence provided by this analysis, suggesting that
acrylamide is not an important risk factor for EC.
Συγγραφείς:
Lujan-Barroso, Leila
Alberto Gonzalez, Carlos
Slimani, Nadia and
Obon-Santacana, Mireia
Ferrari, Pietro
Freisling, Heinz and
Overvad, Kim
Clavel-Chapelon, Francoise
Boutron-Ruault,
Marie-Christine
Racine, Antoine
Katzke, Verena
Kuehn, Tilman
and Tjonneland, Anne
Olsen, Anja
Ramon Quiros, J. and
Sanchez-Cantalejo, Emilio
Amiano, Pilar
Navarro, Carmen and
Barricarte, Aurelio
Khaw, Kay-Tee
Wareham, Nick
Travis, Ruth
C.
Trichopoulou, Antonia
Bamia, Christina
Benetou, Vassiliki
and Saieva, Calogero
Grioni, Sara
Tumino, Rosario
Vineis,
Paolo
Mattiello, Amalia
Bueno-de-Mesquita, H. Bas
Siersema,
Peter D.
Numans, Mattijs E.
Peeters, Petra H.
Ericson,
Ulrika
Wirfaelt, Elisabet
Sund, Malin
Johansson, Mattias and
Weiderpass, Elisabete
Skeie, Guri
Riboli, Elio
Boeing,
Heiner
Duell, Eric J.
