Περίληψη:
We prospectively evaluated fat intake as predictor of developing breast
cancer (BC) subtypes defined by estrogen receptor (ER), progesterone
receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a
large (n = 337 327) heterogeneous cohort of women, with 10 062 BC case
patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox
proportional hazard modeling. High total and saturated fat were
associated with greater risk of ER+PR+ disease (HR = 1.20, 95%
confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to
1.52; highest vs lowest quintiles) but not ER-PR- disease. High
saturated fat was statistically significantly associated with greater
risk of HER2(-) disease. High saturated fat intake particularly
increases risk of receptor-positive disease, suggesting saturated fat
involvement in the etiology of this BC subtype.
Συγγραφείς:
Sieri, Sabina
Chiodini, Paolo
Agnoli, Claudia
Pala, Valeria
and Berrino, Franco
Trichopoulou, Antonia
Benetou, Vassiliki and
Vasilopoulou, Effie
Sanchez, Maria-Jose
Chirlaque, Maria-Dolores
and Amiano, Pilar
Ramon Quiros, J.
Ardanaz, Eva
Buckland,
Genevieve
Masala, Giovanna
Panico, Salvatore
Grioni, Sara
and Sacerdote, Carlotta
Tumino, Rosario
Boutron-Ruault,
Marie-Christine
Clavel-Chapelon, Francoise
Fagherazzi, Guy and
Peeters, Petra H. M.
van Gils, Carla H.
Bueno-de-Mesquita, H.
Bas
van Kranen, Henk J.
Key, Timothy J.
Travis, Ruth C. and
Khaw, Kay Tee
Wareham, Nicholas J.
Kaaks, Rudolf
Lukanova,
Annekatrin
Boeing, Heiner
Schuetze, Madlen
Sonestedt, Emily
and Wirfaelt, Elisabeth
Sund, Malin
Andersson, Anne
Chajes,
Veronique
Rinaldi, Sabina
Romieu, Isabelle
Weiderpass,
Elisabete
Skeie, Guri
Dagrun, Engeset
Tjonneland, Anne and
Halkjaer, Jytte
Overvard, Kim
Merritt, Melissa A.
Cox, David
and Riboli, Elio
Krogh, Vittorio
