Biological insights from 108 schizophrenia-associated genetic loci

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3162395 63 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Biological insights from 108 schizophrenia-associated genetic loci
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Schizophrenia is a highly heritable disorder. Genetic risk is conferred
by a large number of alleles, including common alleles of small effect
that might be detected by genome-wide association studies. Here we
report a multi-stage schizophrenia genome-wide association study of up
to 36,989 cases and 113,075 controls. We identify 128 independent
associations spanning 108 conservatively defined loci that meet
genome-wide significance, 83 of which have not been previously reported.
Associations were enriched among genes expressed in brain, providing
biological plausibility for the findings. Many findings have the
potential to provide entirely new insights into aetiology, but
associations at DRD2 and several genes involved in glutamatergic
neurotransmission highlight molecules of known and potential therapeutic
relevance to schizophrenia, and are consistent with leading
pathophysiological hypotheses. Independent of genes expressed in brain,
associations were enriched among genes expressed in tissues that have
important roles in immunity, providing support for the speculated link
between the immune system and schizophrenia.
Έτος δημοσίευσης:
2014
Συγγραφείς:
Ripke, Stephan
Neale, Benjamin M.
Corvin, Aiden
Walters,
James T. R.
Farh, Kai-How
Holmans, Peter A.
Lee, Phil and
Bulik-Sullivan, Brendan
Collier, David A.
Huang, Hailiang and
Pers, Tune H.
Agartz, Ingrid
Agerbo, Esben
Albus, Margot and
Alexander, Madeline
Amin, Farooq
Bacanu, Silviu A.
Begemann,
Martin
Belliveau, Jr., Richard A.
Bene, Judit
Bergen, Sarah
E.
Bevilacqua, Elizabeth
Bigdeli, Tim B.
Black, Donald W.
and Bruggeman, Richard
Buccola, Nancy G.
Buckner, Randy L. and
Byerley, William
Cahn, Wiepke
Cai, Guiqing
Campion,
Dominique
Cantor, Rita M.
Carr, Vaughan J.
Carrera, Noa and
Catts, Stanley V.
Chambert, Kimberly D.
Chan, Raymond C. K. and
Chen, Ronald Y. L.
Chen, Eric Y. H.
Cheng, Wei
Cheung, Eric
F. C.
Chong, Siow Ann
Cloninger, C. Robert
Cohen, David and
Cohen, Nadine
Cormican, Paul
Craddock, Nick
Crowley, James
J.
Curtis, David
Davidson, Michael
Davis, Kenneth L. and
Degenhardt, Franziska
Del Favero, Jurgen
Demontis, Ditte and
Dikeos, Dimitris
Dinan, Timothy
Djurovic, Srdjan
Donohoe,
Gary
Drapeau, Elodie
Duan, Jubao
Dudbridge, Frank and
Durmishi, Naser
Eichhammer, Peter
Eriksson, Johan and
Escott-Price, Valentina
Essioux, Laurent
Fanous, Ayman H. and
Farrell, Martilias S.
Frank, Josef
Franke, Lude
Freedman,
Robert
Freimer, Nelson B.
Friedl, Marion
Friedman, Joseph I.
and Fromer, Menachem
Genovese, Giulio
Georgieva, Lyudmila and
Giegling, Ina
Giusti-Rodriguez, Paola
Godard, Stephanie and
Goldstein, Jacqueline I.
Golimbet, Vera
Gopal, Srihari and
Gratten, Jacob
de Haan, Lieuwe
Hammer, Christian
Hamshere,
Marian L.
Hansen, Mark
Hansen, Thomas
Haroutunian, Vahram
and Hartmann, Annette M.
Henskens, Frans A.
Herms, Stefan and
Hirschhorn, Joel N.
Hoffmann, Per
Hofman, Andrea
Hollegaard,
Mads V.
Hougaard, David M.
Ikeda, Masashi
Joa, Inge and
Julia, Antonio
Kahn, Rene S.
Kalaydjieva, Luba and
Karachanak-Yankova, Sena
Karjalainen, Juha
Kavanagh, David and
Keller, Matthew C.
Kennedy, James L.
Khrunin, Andrey
Kim,
Yunjung
Klovins, Janis
Knowles, James A.
Konte, Bettina and
Kucinskas, Vaidutis
Kucinskiene, Zita Ausrele
Kuzelova-Ptackova,
Hana
Kahler, Anna K.
Laurent, Claudine
Keong, Jimmy Lee Chee
and Lee, S. Hong
Legge, Sophie E.
Lerer, Bernard
Li, Miaoxin
and Li, Tao
Liang, Kung-Yee
Lieberman, Jeffrey
Limborska,
Svetlana
Loughland, Carmel M.
Lubinski, Jan
Lonnqvist, Jouko
and Macek, Jr., Milan
Magnusson, Patrik K. E.
Maher, Brion S.
and Maier, Wolfgang
Mallet, Jacques
Marsal, Sara
Mattheisen,
Manuel
Mattingsdal, Morten
McCarley, Robert W.
McDonald,
Colm
McIntosh, Andrew M.
Meier, Sandra
Meijer, Carin J. and
Melegh, Bela
Melle, Ingrid
Mesholam-Gately, Raquelle I. and
Metspalu, Andres
Michie, Patricia T.
Milani, Lili
Milanova,
Vihra
Mokrab, Younes
Morris, Derek W.
Mors, Ole
Murphy,
Kieran C.
Murray, Robin M.
Myin-Germeys, Inez and
Mueller-Myhsok, Bertram
Nelis, Mari
Nenadic, Igor
Nertney,
Deborah A.
Nestadt, Gerald
Nicodemus, Kristin K. and
Nikitina-Zake, Liene
Nisenbaum, Laura
Nordin, Annelie and
O'Callaghan, Eadbhard
O'Dushlaine, Colm
O'Neill, F. Anthony and
Oh, Sang-Yun
Olincy, Ann
Olsen, Line
Van Os, Jim and
Pantelis, Christos
Papadimitriou, George N.
Papiol, Sergi and
Parkhomenko, Elena
Pato, Michele T.
Paunio, Tiina and
Pejovic-Milovancevic, Milica
Perkins, Diana O.
Pietilainen, Olli
and Pimm, Jonathan
Pocklington, Andrew J.
Powell, John and
Price, Alkes
Pulver, Ann E.
Purcell, Shaun M.
Quested, Digby
and Rasmussen, Henrik B.
Reichenberg, Abraham
Reimers, Mark A.
and Richards, Alexander L.
Roffman, Joshua L.
Roussos, Panos and
Ruderfer, Douglas M.
Salomaa, Veikko
Sanders, Alan R. and
Schall, Ulrich
Schubert, Christian R.
Schulze, Thomas G. and
Schwab, Sibylle G.
Scolnick, Edward M.
Scott, Rodney J. and
Seidman, Larry J.
Shi, Jianxin
Sigurdsson, Engilbert and
Silagadze, Teimuraz
Silverman, Jeremy M.
Sim, Kang and
Slominsky, Petr
Smoller, Jordan W.
So, Hon-Cheong
Spencer,
Chris C. A.
Stahl, Eli A.
Stefansson, Hreinn
Steinberg,
Stacy
Stogmann, Elisabeth
Straub, Richard E.
Strengman, Eric
and Strohmaier, Jana
Stroup, T. Scott
Subramaniam, Mythily and
Suvisaari, Jaana
Svrakic, Dragan M.
Szatkiewicz, Jin P. and
Soderman, Erik
Thirumalai, Srinivas
Toncheva, Draga
Tosato,
Sarah
Veijola, Juha
Waddington, John
Walsh, Dermot
Wang,
Dai
Wang, Qiang
Webb, Bradley T.
Weiser, Mark and
Wildenauer, Dieter B.
Williams, Nigel M.
Williams, Stephanie and
Witt, Stephanie H.
Wolen, Aaron R.
Wong, Emily H. M. and
Wormley, Brandon K.
Xi, Hualin Simon
Zai, Clement C.
Zheng,
Xuebin
Zimprich, Fritz
Wray, Naomi R.
Stefansson, Kari and
Visscher, Peter M.
Adolfsson, Rolf
Andreassen, Ole A. and
Blackwood, Douglas H. R.
Bramon, Elvira
Buxbaum, Joseph D. and
Borglum, Anders D.
Cichon, Sven
Darvasi, Ariel
Domenici,
Enrico
Ehrenreich, Hannelore
Esko, Tonu
Gejman, Pablo V. and
Gill, Michael
Gurling, Hugh
Hultman, Christina M.
Iwata,
Nakao
Jablensky, Assen V.
Jonsson, Erik G.
Kendler, Kenneth
S.
Kirov, George
Knight, Jo
Lencz, Todd
Levinson,
Douglas F.
Li, Qingqin S.
Liu, Jianjun
Malhotra, Anil K. and
McCarroll, Steven A.
McQuillin, Andrew
Moran, Jennifer L. and
Mortensen, Preben B.
Mowry, Bryan J.
Noethen, Markus M. and
Ophoff, Roel A.
Owen, Michael J.
Palotie, Aarno
Pato, Carlos
N.
Petryshen, Tracey L.
Posthuma, Danielle
Rietschel,
Marcella
Riley, Brien P.
Rujescu, Dan
Sham, Pak C. and
Sklar, Pamela
St Clair, David
Weinberger, Daniel R. and
Wendland, Jens R.
Werge, Thomas
Daly, Mark J.
Sullivan,
Patrick F.
O'Donovan, Michael C.
Psychiat Genomics Consortium
and Psychosis Endophenotypes Int Conso
Wellcome Trust Case-Control
Consor
Περιοδικό:
Nature Metabolism
Εκδότης:
Nature Publishing Group
Τόμος:
511
Αριθμός / τεύχος:
7510
Σελίδες:
421+
Επίσημο URL (Εκδότης):
DOI:
10.1038/nature13595
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