Περίληψη:
Background and purpose: Apolipropotein E(apoE) is a plasma protein
exhibiting three common isoforms (E2, E3, E4). Its involvement in
lipoprotein metabolism may have an impact on stroke occurrence. As
results in the literature are inconclusive further studies are needed to
elucidate its role. Our objective was to study the role of apoE isoforms
and the interplay with environmental risk factors in patients with first
ischaemic stroke occurrence in the Greek population.
Methods: Three hundred and twenty-nine patients with first-ever
ischaemic stroke were included in our study. Strokes of cardioembolic
origin and patients with autoimmune or prothrombotic syndromes were
excluded. A control group of 361 subjects with no stroke history were
also included in our study. Risk factors (hyperlipidemia, hypertension,
diabetes mellitus and smoking) were assessed. ApoE alleles were
determined in all subjects participating in the study.
Results: Genotype epsilon 3/epsilon 3 was found to have a protective
role against stroke occurrence compared with other genotypes (odds ratio
0.674, 95% confidence interval 0.480-0.946) especially in the female
patient subgroup. In multivariate analysis after adjustment for age,
body mass index (BMI), hypertension, dyslipidemia, diabetes mellitus and
smoking, the role of genotype was limited and outweighed by risk factors
in both genders. No association between apoE alleles and BMI,
cholesterol, triglycerides or high-density lipoprotein plasma levels was
noted.
Conclusions: Our study was indicative of a protective role of the
epsilon 3/epsilon 3 genotype, especially in female patients. However,
risk factors such as age, BMI, hypertension, dyslipidemia, diabetes
mellitus and smoking have a strong impact on stroke occurrence and
outweigh the protective role of the epsilon 3/epsilon 3 genotype.
Συγγραφείς:
Chatzistefanidis, D.
Giannopoulos, S.
Spengos, K. and
Vassilopoulou, S.
Vemmos, K.
Dova, L.
Vartholomatos, G. and
Kyritsis, A. P.
Georgiou, I.
Markoula, S.
