Τίτλος:
The clinical significance of cytology versus histology-based diagnosis
in small cell lung cancer: A retrospective study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives: The aim of this study was to investigate the clinical
significance of cytology versus histology-based diagnosis among patients
diagnosed with small cell lung cancer (SCLC).
Materials and methods: Retrospective analysis of medical records of 443
patients with histologically or cytologically confirmed small cell lung
carcinoma (SCLC) was performed. All patients received platinum-based
chemotherapy regimens. Survival data (overall survival) were compared
between patients with histology or cytology-based diagnosis in the
overall study population as well as after stratification of patients
according to disease stage (limited or extensive) at the time of
diagnosis.
Results: Distribution of demographics and clinicopathological
characteristics among the two groups (”histology” and
“cytology”) was similar. No statistically significant differences in
the survival curves between the “histology” and “cytology”
groups were found in the overall study population (log rank test, p =
0.237), as well as in the subgroup of patients with limited disease (log
rank test, p = 0.474). In contrast, patients with histology-based
diagnosis had a statistically significant longer survival as compared to
those with cytology-based diagnosis in the extensive disease subgroup
(log rank test, p = 0.031), but this association was not retained after
adjusting the analysis for demographics and clinical characteristics via
a Cox regression model (HR = 1.18, 95% CI: 0.96-1.44, p = 0.110).
Conclusion: The results of our study suggest that the type of diagnostic
modality employed (histology or cytology-based) for the establishment of
a diagnosis of SCLC may not have a significant effect on the overall
survival of patients. Further studies are warranted to further
investigate this important, yet rather unexplored, issue. (C) 2014
Elsevier Ireland Ltd. All rights reserved.
Συγγραφείς:
Strimpakos, Alexios
Politi, Ekaterini
Kainis, Elias
Grapsa,
Dimitra
Siolos, Spiros
Tsagouli, Sofia
Trigidou, Rodoula and
Syrigos, Konstantinos
Περιοδικό:
Translational Lung Cancer Research
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
Histology; Cytology; Small cell lung carcinoma (SCLC); Survival;
Diagnostic accuracy; Prognosis
DOI:
10.1016/j.lungcan.2014.04.015
