Περίληψη:
We performed a multistage genome-wide association study including 7,683
individuals with pancreatic cancer and 14,397 controls of European
descent. Four new loci reached genome-wide significance: rs6971499 at
7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence
interval (CI) 0.74-0.84, P = 3.0 x 10(-12)), rs7190458 at 16q23.1
(BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 x 10(-10)),
rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 x
10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25,
P = 1.2 x 10(-8)). We identified an independent signal in exon 2 of TERT
at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI
0.76-0.85, P = 9.8 x 10(-14)). We also identified a locus at 8q24.21
(rs1561927, P = 1.3 x 10(-7)) that approached genome-wide significance
located 455 kb telomeric of PVT1. Our study identified multiple new
susceptibility alleles for pancreatic cancer that are worthy of
follow-up studies.
Συγγραφείς:
Wolpin, Brian M.
Rizzato, Cosmeri
Kraft, Peter
Kooperberg,
Charles
Petersen, Gloria M.
Wang, Zhaoming
Arslan, Alan A.
and Beane-Freeman, Laura
Bracci, Paige M.
Buring, Julie and
Canzian, Federico
Duell, Eric J.
Gallinger, Steven
Giles,
Graham G.
Goodman, Gary E.
Goodman, Phyllis J.
Jacobs, Eric
J.
Kamineni, Aruna
Klein, Alison P.
Kolonel, Laurence N. and
Kulke, Matthew H.
Li, Donghui
Malats, Nuria
Olson, Sara H.
and Risch, Harvey A.
Sesso, Howard D.
Visvanathan, Kala and
White, Emily
Zheng, Wei
Abnet, Christian C.
Albanes,
Demetrius
Andreotti, Gabriella
Austin, Melissa A.
Barfield,
Richard
Basso, Daniela
Berndt, Sonja I.
Boutron-Ruault,
Marie-Christine
Brotzman, Michelle
Buechler, Markus W. and
Bueno-de-Mesquita, H. Bas
Bugert, Peter
Burdette, Laurie and
Campa, Daniele
Caporaso, Neil E.
Capurso, Gabriele
Chung,
Charles
Cotterchio, Michelle
Costello, Eithne
Elena, Joanne
and Funel, Niccola
Gaziano, J. Michael
Giese, Nathalia A. and
Goggins, Michael
Gorman, Megan J.
Gross, Myron
Haiman,
Christopher A.
Hassan, Manal
Helzlsouer, Kathy J.
Henderson,
Brian E.
Holly, Elizabeth A.
Hu, Nan
Hunter, David J. and
Innocenti, Federico
Jenab, Mazda
Kaaks, Rudolf
Key, Timothy
J.
Khaw, Kay-Tee
Klein, Eric A.
Kogevinas, Manolis and
Krogh, Vittorio
Kupcinskas, Juozas
Kurtz, Robert C.
LaCroix,
Andrea
Landi, Maria T.
Landi, Stefano
Le Marchand, Loic and
Mambrini, Andrea
Mannisto, Satu
Milne, Roger L.
Nakamura,
Yusuke
Oberg, Ann L.
Owzar, Kouros
Patel, Alpa V. and
Peeters, Petra H. M.
Peters, Ulrike
Pezzilli, Raffaele and
Piepoli, Ada
Porta, Miquel
Real, Francisco X.
Riboli, Elio
and Rothman, Nathaniel
Scarpa, Aldo
Shu, Xiao-Ou
Silverman,
Debra T.
Soucek, Pavel
Sund, Malin
Talar-Wojnarowska, Renata
and Taylor, Philip R.
Theodoropoulos, George E.
Thornquist, Mark
and Tjonneland, Anne
Tobias, Geoffrey S.
Trichopoulos, Dimitrios
and Vodicka, Pavel
Wactawski-Wende, Jean
Wentzensen, Nicolas and
Wu, Chen
Yu, Herbert
Yu, Kai
Zeleniuch-Jacquotte, Anne and
Hoover, Robert
Hartge, Patricia
Fuchs, Charles
Chanock,
Stephen J.
Stolzenberg-Solomon, Rachael S.
Amundadottir, Laufey
T.
