Περίληψη:
The association between vitamin D status and hepatocellular carcinoma
(HCC) has not been well investigated, despite experimental evidence
supporting an important role of vitamin D in liver pathophysiology. Our
objective was to investigate the association between prediagnostic
circulating 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of
HCC in a prospective, nested case-control study among 520,000
participants in the European Prospective Investigation into Cancer and
Nutrition (EPIC) cohort. Each case (n=138) diagnosed between 1992 and
2010 was matched to one control by age, sex, study center, date and time
of blood collection, and fasting status. Serum baseline levels of
25(OH)D were measured by liquid chromatography/tandem mass spectrometry.
Multivariable incident rate ratios (IRRs) of HCC associated with
continuous (per 10 nmol/L) or categorical levels (tertiles or a
priori-defined categories) of prediagnostic 25(OH)D were calculated
using conditional logistic regression. Higher 25(OH)D levels were
associated with a 49% reduction in the risk of HCC (highest versus
lowest tertile: multivariable IRR=0.51, 95% confidence interval [CI],
0.26 to 0.99; P-trend=0.04; per 10 nmol/L increase: IRR=0.80, 95% CI,
0.68-0.94). The finding did not vary substantially by time from
enrolment to diagnosis, and did not change after adjustment for
biomarkers of preexisting liver damage, nor chronic infection with
hepatitis B or C viruses. The findings were not modified by body size or
smoking status. Conclusion: In this prospective study on western
European populations, serum levels of 25(OH)D were inversely associated
with the risk of HCC. Given the rising incidence of this cancer in
low-risk developed countries and the strong public health interest
surrounding the potentially cancer-protective roles of vitamin D,
additional studies in different populations are required. (Hepatology
2014;60:1222-1230)
Συγγραφείς:
Fedirko, Veronika
Duarte-Salles, Talita
Bamia, Christina and
Trichopoulou, Antonia
Aleksandrova, Krasimira
Trichopoulos,
Dimitrios
Trepo, Elisabeth
Tjonneland, Anne
Olsen, Anja and
Overvad, Kim
Boutron-Ruault, Marie-Christine
Clavel-Chapelon,
Francoise
Kvaskoff, Marina
Kuehn, Tilman
Lukanova, Annie and
Boeing, Heiner
Buijsse, Brian
Klinaki, Eleni
Tsimakidi,
Chrysanthi
Naccarati, Alessio
Tagliabue, Giovanna
Panico,
Salvatore
Tumino, Rosario
Palli, Domenico
Bueno-de-Mesquita,
H. Bas
Siersema, Peter D.
Peters, Petra H.
Lund, Eiliv and
Brustad, Magritt
Olsen, Karina Standahl
Weiderpass, Elisabete
and Zamora-Ros, Raul
Sanchez, Maria-Jose
Ardanaz, Eva and
Amiano, Pilar
Navarro, Carmen
Ramon Quiros, J.
Werner,
Marten
Sund, Malin
Lindkvist, Bjorn
Malm, Johan
Travis,
Ruth C.
Khaw, Kay-Tee
Stepien, Magdalena
Scalbert, Augustin
and Romieu, Isabelle
Lagiou, Pagona
Riboli, Elio
Jenab,
Mazda
