Περίληψη:
Background: There is growing evidence of the protective role of dietary
intake of flavonoids and lignans on cancer, but the association with
bladder cancer has not been thoroughly investigated in epidemiological
studies. We evaluated the association between dietary intakes of total
and subclasses of flavonoids and lignans and risk of bladder cancer and
its main morphological type, urothelial cell carcinoma (UCC), within the
European Prospective Investigation into Cancer and Nutrition (EPIC)
study.
Methods: A cohort of 477 312 men and women mostly aged 35-70 years, were
recruited in 10 European countries. At baseline, dietary flavonoid and
lignan intakes were estimated using centre-specific validated
questionnaires and a food composition database based on the
Phenol-Explorer, the UK Food Standards Agency and the US Department of
Agriculture databases.
Results: During an average of 11 years of follow-up, 1575 new cases of
primary bladder cancer were identified, of which 1425 were UCC
(classified into aggressive (n = 430) and non-aggressive (n = 413) UCC).
No association was found between total flavonoid intake and bladder
cancer risk. Among flavonoid subclasses, significant inverse
associations with bladder cancer risk were found for intakes of flavonol
(hazard ratio comparing fifth with first quintile (HRQ5-Q1) 0.74, 95%
confidence interval (CI): 0.61-0.91; P-trend = 0.009) and lignans
(HRQ5-Q 10.78, 95% CI: 0.62-0.96; P-trend = 0.046). Similar results
were observed for overall UCC and aggressive UCC, but not for
non-aggressive UCC.
Conclusions: Our study suggests an inverse association between the
dietary intakes of flavonols and lignans and risk of bladder cancer,
particularly aggressive UCC.
Συγγραφείς:
Zamora-Ros, R.
Sacerdote, C.
Ricceri, F.
Weiderpass, E. and
Roswall, N.
Buckland, G.
St-Jules, D. E.
Overvad, K. and
Kyro, C.
Fagherazzi, G.
Kvaskoff, M.
Severi, G. and
Chang-Claude, J.
Kaaks, R.
Noethlings, U.
Trichopoulou, A.
and Naska, A.
Trichopoulos, D.
Palli, D.
Grioni, S. and
Mattiello, A.
Tumino, R.
Gram, I. T.
Engeset, D.
Huerta,
J. M.
Molina-Montes, E.
Argueelles, M.
Amiano, P. and
Ardanaz, E.
Ericson, U.
Lindkvist, B.
Nilsson, L. M. and
Kiemeney, L. A.
Ros, M.
Bueno-de-Mesquita, H. B.
Peeters, P.
H. M.
Khaw, K-T
Wareham, N. J.
Knaze, V.
Romieu, I. and
Scalbert, A.
Brennan, P.
Wark, P.
Vineis, P.
Riboli, E.
and Gonzalez, C. A.
