Περίληψη:
Background The etiology of renal cell carcinoma (RCC) is only partially
understood, but a metabolic component appears likely. We investigated
biomarkers of one-carbon metabolism and RCC onset and survival.
Methods The European Prospective Investigation into Cancer and Nutrition
(EPIC) recruited 385 747 participants with blood samples between 1992
and 2000, and this analysis included 556 RCC case-control pairs. A
subsequent replication study included 144 case-control pairs nested
within the Melbourne Collaborative Cohort Study (MCCS). Plasma
concentrations of vitamin B2, vitamin B6, folate, vitamin B12,
methionine and homocysteine were measured in prediagnostic samples and
evaluated with respect to RCC risk using conditional and unconditional
logistic regression models, and to all-cause mortality in RCC cases
using Cox regression models. All statistical tests were two-sided.
Results EPIC participants with higher plasma concentrations of vitamin
B6 had lower risk of RCC, the odds ratio comparing the 4th and 1st
quartiles (OR4vs1) being 0.40 95% confidence interval [CI] = 0.28 to
0.57, P-trend < .001. We found similar results after adjusting for
potential confounders (adjusted P-trend < .001). In survival analysis,
the hazard ratio for all-cause mortality in RCC cases when comparing the
4th and 1st quartiles (HR4vs1) of vitamin B6 was 0.57 (95% CI = 0.37 to
0.87, P-trend < .001). Subsequent replication of these associations
within the MCCS yielded very similar results for both RCC risk (OR4vs1 =
0.47, 95% CI = 0.23 to 0.99, P-trend = .07) and all-cause mortality
(HR4vs1 = 0.56, 95% CI = 0.27 to 1.17, P-trend = .02). No association
was evident for the other measured biomarkers.
Conclusion Study participants with higher circulating concentrations of
vitamin B6 had lower risk of RCC and improved survival following
diagnosis in two independent cohorts.
Συγγραφείς:
Johansson, Mattias
Fanidi, Anouar
Muller, David C.
Bassett,
Julie K.
Midttun, Oivind
Vollset, Stein Emil
Travis, Ruth C.
and Palli, Domenico
Mattiello, Amalia
Sieri, Sabina and
Trichopoulou, Antonia
Lagiou, Pagona
Trichopoulos, Dimitrios and
Ljungberg, Borje
Hallmans, Goran
Weiderpass, Elisabete and
Skeie, Guri
Gonzalez, Carlos A.
Dorronsoro, Miren
Peeters,
Petra H.
Bueno-de-Mesquita, H. B(as).
Ros, Martine M. and
Ruault, Marie-Christine Boutron
Fagherazzi, Guy
Clavel,
Francoise
Sanchez, Maria-Jose
Barricarte Gurrea, Aurelio and
Navarro, Carmen
Ramon Quiros, J.
Overvad, Kim
Tjonneland,
Anne
Aleksandrova, Krassimira
Vineis, Paolo
Gunter, Marc J.
and Kaaks, Rudolf
Giles, Graham
Relton, Caroline
Riboli,
Elio
Boeing, Heiner
Ueland, Per Magne
Severi, Gianluca and
Brennan, Paul
