Τίτλος:
Endothelial dysfunction in conduit arteries and in microcirculation.
Novel therapeutic approaches
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The vascular endothelium not only is a single monolayer of cells between
the vessel lumen and the intimal wall, but also plays an important role
by controlling vascular function and structure mainly via the production
of nitric oxide (NO). The so called “cardiovascular risk factors”
are associated with endothelial dysfunction, that reduces NO
bioavailability, increases oxidative stress, and promotes inflammation
contributing therefore to the development of atherosclerosis. The
significant role of endothelial dysfunction in the development of
atherosclerosis emphasizes the need for efficient therapeutic
interventions.
During the last years statins, angiotensin-converting enzyme inhibitors,
angiotensin-receptor antagonists, antioxidants, beta-blockers and
insulin sensitizers have been evaluated for their ability to restore
endothelial function (Briasoulis et al., 2012). As there is not a
straightforward relationship between therapeutic interventions and
improvement of endothelial function but rather a complicated
interrelationship between multiple cellular and sub-cellular targets,
research has been focused on the understanding of the underlying
mechanisms. Moreover, the development of novel diagnostic invasive and
non-invasive methods has allowed the early detection of endothelial
dysfunction expanding the role of therapeutic interventions and our
knowledge.
In the current review we present the available data concerning the
contribution of endothelial dysfunction to atherogenesis and review the
methods that assess endothelial function with a view to understand the
multiple targets of therapeutic interventions. Finally we focus on the
classic and novel therapeutic approaches aiming to improve endothelial
dysfunction and the underlying mechanisms. (C) 2014 Elsevier Inc. All
rights reserved.
Συγγραφείς:
Tousoulis, Dimitris
Simopoulou, Chryssa
Papageorgiou, Nikos and
Oikonomou, Evangelos
Hatzis, George
Siasos, Gerasimos and
Tsiamis, Eleftherios
Stefanadis, Christodoulos
Περιοδικό:
Alimentary Pharmacology & Therapeutics
Εκδότης:
PERGAMON-ELSEVIER SCIENCE LTD
Λέξεις-κλειδιά:
Atherosclerosis; Cardiovascular disease; Endothelial function;
Therapeutic approaches
DOI:
10.1016/j.pharmthera.2014.06.003
