Περίληψη:
Objective. The aim of this study was to validate the classification
criteria for cryoglobulinaemic vasculitis (CV).
Methods. Twenty-three centres were involved. New patients with CV (group
A) and controls, i.e. subjects with serum cryoglobulins but lacking CV
based on the gold standard of clinical judgment (group B) and subjects
without cryoglobulins but with clinical features that can be observed in
the course of CV (group C), were studied. Positivity of serum
cryoglobulins was necessary for CV classification. Sensitivity and
specificity of the criteria were calculated by comparing group A vs
group B. The group A vs group C comparison was done to demonstrate the
possible diagnostic utility of the criteria.
Results. The study included 268 patients in group A, 182 controls in
group B and 193 controls in group C (small vessel vasculitis, 51.8%).
The questionnaire (at least 2/3 positive answers) showed 89.0%
sensitivity and 93.4% specificity; the clinical item (at least 3/4
clinical involvement) showed 75.7% sensitivity and 89.0% specificity
and the laboratory item (at least 2/3 laboratory data) showed 80.2%
sensitivity and 62.4% specificity. The sensitivity and specificity of
the classification criteria (at least 2/3 positive items) were 89.9%
and 93.5%, respectively. The comparison of group A with group C
demonstrated the clinical utility of the criteria in differentiating CV
from CV mimickers.
Conclusion. Classification criteria for CV were validated in a second,
large, international study confirming good sensitivity and specificity
in a complex systemic disease.
Συγγραφείς:
Quartuccio, Luca
Isola, Miriam
Corazza, Laura
Ramos-Casals,
Manuel
Retamozo, Soledad
Ragab, Gaafar Mohamed
Zoheir,
Mostafa Naguib
El-Menyawi, Manal Abdel-Moneim
Salem, Mohamed
Nabil
Sansonno, Domenico
Ferraccioli, Gianfranco
Gremese,
Elisa
Tzioufas, Athanasios
Voulgarelis, Michael and
Vassilopoulos, Dimitris
Scarpato, Salvatore
Pipitone, Nicolo and
Salvarani, Carlo
Guillevin, Loic
Terrier, Benjamin
Cacoub,
Patrice
Filippini, Davide
Saccardo, Francesco
Gabrielli,
Armando
Fraticelli, Paolo
Sebastiani, Marco
Tomsic, Matija
and Tavoni, Antonio
Mazzaro, Cesare
Pioltelli, Pietro and
Nishimoto, Norihiro
Scaini, Patrizia
Zignego, Anna Linda and
Ferri, Clodoveo
Monti, Giuseppe
Pietrogrande, Maurizio and
Bombardieri, Stefano
Galli, Massimo
De Vita, Salvatore
