Περίληψη:
Long-term weight gain (i.e., weight gain since age 20) has been related
to higher risk of postmenopausal breast cancer, but a lower risk of
premenopausal breast cancer. The effect of weight change in middle
adulthood is unclear. We investigated the association between weight
change in middle adulthood (i.e., women aged 40-50 years) and the risk
of breast cancer before and after the age of 50. We included female
participants of the European Prospective Investigation into Cancer and
Nutrition cohort, with information on anthropometric measures at
recruitment and after a median follow-up of 4.3 years. Annual weight
change was categorized using quintiles taking quintile 2 and 3 as the
reference category (-0.44 to 0.36 kg/year). Multivariable Cox
proportional hazards regression analysis was used to examine the
association. 205,723 women were included and 4,663 incident breast
cancer cases were diagnosed during a median follow-up of 7.5 years (from
second weight assessment onward). High weight gain (Q5: 0.83-4.98
kg/year) was related to a slightly, but significantly higher breast
cancer risk (HRQ5_versus_Q2/3: 1.09, 95% CI: 1.01-1.18). The
association was more pronounced for breast cancer diagnosed before or at
age 50 (HRQ5_versus_Q2/3: 1.37, 95% CI: 1.02-1.85). Weight loss was
not associated with breast cancer risk. There was no evidence for
heterogeneity by hormone receptor status. In conclusion, high weight
gain in middle adulthood increases the risk of breast cancer. The
association seems to be more pronounced for breast cancer diagnosed
before or at age 50. Our results illustrate the importance of avoiding
weight gain in middle adulthood.
Συγγραφείς:
Emaus, Marleen J.
van Gils, Carla H.
Bakker, Marije F. and
Bisschop, Charlotte N. Steins
Monninkhof, Evelyn M. and
Bueno-de-Mesquita, H. B(as)
Travier, Noemie
Berentzen, Tina
Landsvig
Overvad, Kim
Tjonneland, Anne
Romieu, Isabelle and
Rinaldi, Sabina
Chajes, Veronique
Gunter, Marc J. and
Clavel-Chapelon, Francoise
Fagherazzi, Guy
Mesrine, Sylvie and
Chang-Claude, Jenny
Kaaks, Rudolf
Boeing, Heiner and
Aleksandrova, Krasimira
Trichopoulou, Antonia
Naska, Androniki
and Orfanos, Philippos
Palli, Domenico
Agnoli, Claudia and
Tumino, Rosario
Vineis, Paolo
Mattiello, Amalia
Braaten,
Tonje
Borch, Kristin Benjaminsen
Lund, Eiliv
Menendez,
Virginia
Sanchez, Maria-Jose
Navarro, Carmen
Barricarte,
Aurelio
Amiano, Pilar
Sund, Malin
Andersson, Anne and
Borgquist, Signe
Olsson, Asa
Khaw, Kay-Tee
Wareham, Nick and
Travis, Ruth C.
Riboli, Elio
Peeters, Petra H. M.
May, Anne
M.
