Τίτλος:
Effects of CYP2C19 Polymorphism on Endothelial Function, Arterial
Stiffness and Inflammation in Coronary Artery Disease Patients Under
Clopidogrel Treatment
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Clopidogrel’s ability to inhibit platelet function
determined its clinical usefulness. The role of CYP2C19*2 genotype on
antiplatelet treatment is recently under question. Arterial wall
properties and inflammation are key players in atherosclerosis
development. Hence, we evaluated the impact of CYP2C19*2 genetic
polymorphism on endothelial function, arterial stiffness and
inflammation in coronary artery disease (CAD) patients receiving
clopidogrel treatment.
Methods and Results: In this study we enrolled 408 consecutive patients
with stable CAD under dual antiplatelet therapy (clopidogrel 75mg/day,
aspirin 100mg/day), 30 days after percutaneous coronary intervention.
Measurement of flow-mediated dilation (FMD) of the brachial artery was
used to evaluate endothelial function. Carotid-femoral pulse wave
velocity (PWV) and augmentation index (AIx) was measured to estimate
arterial stiffness. Real time polymerase chain reaction was used for the
genotyping of CYP2C19*2. Levels of tumor necrosis factor alpha (TNF-a)
and interleukin 6 (IL-6) were measured with ELISA. We found no
difference in basic clinical and demographic characteristics nor in FMD,
PWV, AIx and inflammatory status (p=NS for all) between CYP2C19
homozygotes for the wild type; carriers of reduced function allele and
homozygotes for the reduced function allele.
Conclusion: CYP2C19*2 loss of action polymorphism causes no impact on
vascular function and inflammatory status in stable CAD patients
receiving clopidogrel treatment.
Συγγραφείς:
Siasos, Gerasimos
Zaromitidou, Marina
Oikonomou, Evangelos and
Mourouzis, Konstantinos
Tsalamandris, Sotiris
Kioufis, Stamatios
and Kokkou, Eleni
Vavuranakis, Manolis
Zografos, Theodoros and
Antonopoulos, Alexis
Dimitropoulos, Stathis
Stefanadis,
Christodoulos
Papavassiliou, Athanasios G.
Tousoulis, Dimitris
Περιοδικό:
Current Pharmaceutical Design
Εκδότης:
BENTHAM SCIENCE PUBL LTD
Λέξεις-κλειδιά:
Arterial stiffness; atherosclerosis; clopidogrel; coronary artery
disease; endothelial function; inflammation; polymorphisms; vascular
endothelium
DOI:
10.2174/1381612821666150827124459
