Τίτλος:
Prognostic Significance of Serum Inflammatory Response Markers in Newly
Diagnosed Non-Small Cell Lung Cancer before Chemoirradiation
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose. To identify whether the serum’s baseline C-reactive protein
(CRP) and albumin (Alb) levels related to clinicopathological parameters
and overall survival (OS) in non-small cell lung cancer (NSCLC).
Methods. In total, 100 consecutive patients (mean age = 68.38 +/- 10.85
years) that underwent chemoradiotherapy were studied. Measurements of
CRP and Alb were performed before any treatment. Results. Serum CRP
levels were significantly associated with histological grade (P <
0.001), TNM stage (P < 0.001), PS (P = 0.009), and Alb (P < 0.001).
Additionally CRP and Alb levels were found significantly associated with
overall survival in univariate analysis (log-rank test, P < 0.001 and P
= 0.002, resp.) and CRP remained significant after controlling for age,
alcohol, performance status, and TNM stage, whereas albumin showed a
borderline effect on the hazard rate (P = 0.052). Conclusions. CRP and
Alb are both promising biomarkers in identification of NSCLC patients
with poor prognosis and form a possible target for intensifying their
therapies.
Συγγραφείς:
Tolia, Maria
Tsoukalas, Nikolaos
Kyrgias, George
Mosa,
Eftychia
Maras, Apostolos
Kokakis, Ioannis
Liakouli, Zoi and
Kouvaris, John R.
Liaskonis, Konstantinos
Charalampakis,
Nikolaos
Pistevou-Gombaki, Kyriaki
Kelekis, Nikolaos and
Kouloulias, Vassilis
Περιοδικό:
BioMed Research International
