Τίτλος:
Does patient education work in breast cancer? Final results from the
global CARIATIDE study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aim: To determine the impact of educational materials (EMs) on the
treatment compliance of postmenopausal women with hormone
receptor-positive (HR+) early-stage breast cancer. Patients & methods:
Patients (n = 2757) were randomized to standard aromatase inhibitors
(AI) alone (group A) or with EMs (group B) in a global, real-world
setting. Results: The 2-year results (n = 2242) showed EMs had no impact
on compliance (82 vs 82%, group A vs B), compliance with initial AI (82
vs 81%) or persistence (90 vs 88%), confirming the 1-year interim
analysis (n = 2567). Of the 2082 patients considered compliant at 1
year, 77% remained compliant at 2 years. Discontinuations (9%) were
mainly attributed to AI-related side effects (68% of discontinuations).
Exploratory analyses suggest a relationship between patient
characteristics and compliance behaviors. Conclusion: EMs do not improve
compliance in this patient population. Compliance and persistence are
complex end points influenced by multiple variables. Side effects were
the main reasons for discontinuations.
Συγγραφείς:
Markopoulos, Christos
Neven, Patrick
Tanner, Minna
Marty,
Michael
Kreienberg, Rolf
Atkins, Louise
Franquet, Ann and
Gnant, Michael
Neciosup, Silvia
Tesarova, Petra
Barni,
Sandro
Deschamp, Veronique
Περιοδικό:
Future oncology (London, England)
Εκδότης:
Future Medicine Ltd
Λέξεις-κλειδιά:
adherence; anastrozole; aromatase inhibitor; breast cancer; compliance;
letrozole; persistence
