Τίτλος:
Microvessel Landscape Assessment in Pancreatic Ductal Adenocarcinoma
Unclear Value of Targeting Endoglin (CD105) as Prognostic Factor of
Clinical Outcome
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives Tumor angiogenesis based on microvessel density assessment
has been associated with poor prognosis in several studies of patients
with pancreatic ductal adenocarcinoma (PDAC). Expression of endoglin
(CD105), a tumor-induced vascularization marker, has been found to
represent a negative prognostic factor in many malignant tumors. The aim
of our study was to assess the value of tumoral microvascularity both
with pan-endothelial markers and endoglin as well, in correlation with
the clinical outcome of patients with PDAC.
Methods Fifty-eight patients with PDAC, 36 males and 22 females, with a
mean (SD) age of 65.4 (10.0) years were included in the study.
Deparaffinized sections from formalin-fixed areas both from the center
and periphery (invasion front) of the tumors were immunostained for
CD105 as well as for the endothelial markers CD31 and CD34. Tumoral
angiogenesis was assessed on the basis of microvessel density (number of
vessels per square millimeter) and on microvascular area (square
micrometers) as well.
Results High intratumoral microvascular area, in endoglin-stained
sections, was found to be of marginal prognostic significance for
recurrence (log rank, P 0.05). Survival was also marginally associated
with CD31 intratumoral microvascular area (log rank, P 0.05).
Conclusions Further studies are needed before endoglin replaces the
conventional angiogenesis markers in PDCA.
Συγγραφείς:
Lytras, Dimitrios
Leontara, Vassileia
Kefala, Maria
Foukas,
Periklis G.
Giannakou, Niki
Pouliakis, Abraham
Dervenis,
Christos
Panayiotides, Ioannis G.
Karakitsos, Petros
Περιοδικό:
Journal of the Pancreas
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
microvessel density; endoglin; CD105; pancreatic adenocarcinoma
DOI:
10.1097/MPA.0000000000000197
