Περίληψη:
There is limited evidence on the association between dietary folate
intake and the risk of breast cancer (BC) by hormone receptor expression
in the tumors. We investigated the relationship between dietary folate
and BC risk using data from the European Prospective Investigation into
Cancer and Nutrition (EPIC).
A total of 367993 women age 35 to 70 years were recruited in 10 European
countries. During a median follow-up of 11.5 years, 11575 women with BC
were identified. Dietary folate intake was estimated from
country-specific dietary questionnaires. Cox proportional hazards
regression models were used to quantify the association between dietary
variables and BC risk. BC tumors were classified by receptor status.
Subgroup analyses were performed by menopausal status and alcohol
intake. Intake of other B vitamins was considered. All statistical tests
were two-sided.
A borderline inverse association was observed between dietary folate and
BC risk (hazard ratio comparing top vs bottom quintile [HRQ5-Q1] =
0.92, 95% CI = 0.83 to 1.01, P (trend) = .037). In premenopausal women,
we observed a statistically significant trend towards lower risk in
estrogen receptor-negative BC (HRQ5-Q1 = 0.66, 95% CI = 0.45 to 0.96, P
(trend) = .042) and progesterone receptor-negative BC (HRQ5-Q1 = 0.70,
95% CI = 0.51 to 0.97, P (trend) = .021). No associations were found in
postmenopausal women. A 14% reduction in BC risk was observed when
comparing the highest with the lowest dietary folate tertiles in women
having a high (> 12 alcoholic drinks/week) alcohol intake (HRT3-T1 =
0.86, 95% CI = 0.75 to 0.98, P (interaction) = .035).
Higher dietary folate intake may be associated with a lower risk of sex
hormone receptor-negative BC in premenopausal women.
Συγγραφείς:
de Batlle, J.
Ferrari, P.
Chajes, V.
Park, J. Y. and
Slimani, N.
McKenzie, F.
Overvad, K.
Roswall, N. and
Tjonneland, A.
Boutron-Ruault, M. C.
Clavel-Chapelon, F. and
Fagherazzi, G.
Katzke, V.
Kaaks, R.
Bergmann, M. M. and
Trichopoulou, A.
Lagiou, P.
Trichopoulos, D.
Palli, D. and
Sieri, S.
Panico, S.
Tumino, R.
Vineis, P. and
Bueno-de-Mesquita, H. B.
Peeters, P. H.
Hjartaker, A. and
Engeset, D.
Weiderpass, E.
Sanchez, S.
Travier, N. and
Sanchez, M. J.
Amiano, P.
Chirlaque, M. D.
Barricarte
Gurrea, A.
Khaw, K. T.
Key, T. J.
Bradbury, K. E. and
Ericson, U.
Sonestedt, E.
Van Guelpen, B.
Schneede, J. and
Riboli, E.
Romieu, I.
