Περίληψη:
Background: Prospective studies on insulin-like growth factor I (IGF-I)
and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest
risk associations vary by tumour characteristics.
Methods: We conducted a nested case-control study in the European
Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate
IGF-I concentrations and EOC risk by tumour characteristics (n = 565
cases). Multivariable conditional logistic regression models were used
to estimate associations.
Results: We observed no association between IGF-I and EOC overall or by
tumour characteristics.
Conclusions: In the largest prospective study to date was no association
between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations
may not influence EOC risk.
Συγγραφείς:
Ose, J.
Fortner, R. T.
Schock, H.
Peeters, P. H. and
Onland-Moret, N. C.
Bueno-de-Mesquita, H. B.
Weiderpass, E. and
Gram, I. T.
Overvad, K.
Tjonneland, A.
Dossus, L. and
Fournier, A.
Baglietto, L.
Trichopoulou, A.
Benetou, V. and
Trichopoulos, D.
Boeing, H.
Masala, G.
Krogh, V. and
Matiello, A.
Tumino, R.
Popovic, M.
Obon-Santacana, M. and
Larranaga, N.
Ardanaz, E.
Sanchez, M-J
Menendez, V. and
Chirlaque, M-D
Travis, R. C.
Khaw, K-T
Braendstedt, J. and
Idahl, A.
Lundin, E.
Rinaldi, S.
Kuhn, E.
Romieu, I. and
Gunter, M. J.
Merritt, M. A.
Riboli, E.
Kaaks, R.
