Τίτλος:
Vitamin D levels and status amongst asthmatic and non-asthmatic
adolescents in Cyprus: a comparative cross-sectional study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Emerging evidence suggests that vitamin D might be
implicated in asthma pathophysiology. This study aims to compare Vitamin
D mean serum levels and status between asthmatic and non-asthmatic
adolescents and investigate the association of vitamin D with asthma
severity.
Methods: In a cohort of adolescents aged 16-17 years, those reporting
wheezing in the past 12 months and Ever asthma on the ISAAC
questionnaire were invited to participate and formed the Active
Asthmatics group. Controls were selected amongst Never Wheezers/Never
Asthmatics (NWNA). Differences in mean 25(OH)D serum levels and vitamin
D status between AA and NWNA were examined in multivariate linear and
logistic regression models respectively, adjusting for potential
confounders. Within AA, differences in vitamin D levels were assessed
across asthma severity indicators.
Results: A total of 69 AA and 671 NWNA participated in the study.
Unadjusted mean 25(OH) D serum levels were 22.90 (SD 6.41), and 21.15
(SD 5.59) ng/mL in NWNA and AA respectively (p = 0.03). In adjusted
models, mean 25(OH) D levels remained significantly lower amongst AA
compared to NWNA (adjusted beta coefficient -1.68, 95% CI -3.24,
-0.13). Severe (<12 ng/mL), moderate (<25 ng/mL) or insufficient (<30
ng/mL) vitamin D status was more prevalent among AA who were 1.6 times
(95% CI 1.01, 2.53) more likely to belong to a lower vitamin D category
compared to NWNA. Within AA, there was a negative trend between vitamin
D levels and the number of reported asthma severity indicators.
Conclusions: Levels of vitamin D tend to be lower among asthmatic
compared to non-asthmatic children and in those with severe asthma
independent of important confounders.
Συγγραφείς:
Kolokotroni, Ourania
Papadopoulou, Anna
Middleton, Nicos and
Kouta, Christiana
Raftopoulos, Vasilios
Nicolaidou, Polyxeni and
Yiallouros, Panayiotis K.
Περιοδικό:
BMC Public Health
Λέξεις-κλειδιά:
Adolescents; Asthma; Asthma severity; Vitamin D levels; Vitamin D status
DOI:
10.1186/s12889-015-1385-2
