Τίτλος:
The impact of metformin treatment on adiponectin and resistin levels in
women with polycystic ovary syndrome: a prospective clinical study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Women with polycystic ovary syndrome (PCOS) are often characterized by
adiposity and insulin resistance (IR). Recent studies in patients with
obesity and diabetes mellitus type 2 (DMt2) indicate that adiponectin
and resistin may play a role in the pathophysiology of IR. The aim of
this study was to identify a possible correlation between the plasma
levels of adiponectin and resistin and IR in patients with PCOS.
Thirty-one women of reproductive age were enrolled in this prospective
study after being diagnosed with PCOS and IR according to Rotterdam and
American Diabetes Association (ADA) criteria, respectively. Every
patient was treated with a daily dose of 1275mg metformin for 6 months.
Adiponectin, resistin, and the primary hormonal and metabolic parameters
of the syndrome were evaluated at entry and endpoint of treatment.
Adiponectin plasma levels were reduced after metformin treatment, but
resistin levels were not significantly affected. Our study suggests that
circulating levels of adiponectin should be evaluated with skepticism in
patients with PCOS. The adipokine’s role in the manifestation of IR in
PCOS remains unclear and needs further investigation.
Συγγραφείς:
Basios, G.
Trakakis, E.
Chrelias, Ch.
Panagopoulos, P. and
Vaggopoulos, V.
Skarpas, P.
Kassanos, D.
Dimitriadis, G. and
Hatziagelaki, E.
Περιοδικό:
Gynecological Endocrinology
Εκδότης:
TAYLOR & FRANCIS LTD LONDON
Λέξεις-κλειδιά:
Adipose tissue; adiponectin; insulin resistance; metformin; resistin
DOI:
10.3109/09513590.2014.975684
