Περίληψη:
Background
Few epidemiological studies have examined the association between
dietary trans fatty acids and weight gain, and the evidence remains
inconsistent. The main objective of the study was to investigate the
prospective association between biomarker of industrial trans fatty
acids and change in weight within the large study European Prospective
Investigation into Cancer and Nutrition ( EPIC) cohort.
Methods
Baseline plasma fatty acid concentrations were determined in a
representative EPIC sample from the 23 participating EPIC centers. A
total of 1,945 individuals were followed for a median of 4.9 years to
monitor weight change. The association between elaidic acid level and
percent change of weight was investigated using a multinomial logistic
regression model, adjusted by length of follow- up, age, energy,
alcohol, smoking status, physical activity, and region.
Results
In women, doubling elaidic acid was associated with a decreased risk of
weight loss ( odds ratio ( OR) = 0.69, 95% confidence interval ( CI) =
0.55- 0.88, p = 0.002) and a trend was observed with an increased risk
of weight gain during the 5- year follow- up ( OR = 1.23, 95% CI =
0.97- 1.56, p = 0.082) ( p- trend<. 0001). In men, a trend was observed
for doubling elaidic acid level and risk of weight loss ( OR = 0.82,
95% CI = 0.66- 1.01, p = 0.062) while no significant association was
found with risk of weight gain during the 5- year follow- up ( OR =
1.08, 95% CI = 0.88- 1.33, p = 0.454). No association was found for
saturated and cismonounsaturated fatty acids.
Conclusions
These data suggest that a high intake of industrial trans fatty acids
may decrease the risk of weight loss, particularly in women. Prevention
of obesity should consider limiting the consumption of highly processed
foods, the main source of industrially- produced trans fatty acids.
Συγγραφείς:
Chajes, Veronique
Biessy, Carine
Ferrari, Pietro
Romieu,
Isabelle
Freisling, Heinz
Huybrechts, Inge
Scalbert,
Augustin
de Mesquita, Bas Bueno
Romaguera, Dora
Gunter, Marc
J.
Vineis, Paolo
Hansen, Camilla Plambeck
Jakobsen, Marianne
Uhre
Clavel-Chapelon, Francoise
Fagherazzi, Guy and
Boutron-Ruault, Marie-Christine
Katzke, Verana
Neamat-Allah,
Jasmine
Boeing, Heiner
Bachlechner, Ursula
Trichopoulou,
Antonia
Naska, Androniki
Orfanos, Philippos
Pala, Valeria
and Masala, Giovanna
Mattiello, Amalia
Skeie, Guri and
Weiderpass, Elisabete
Agudo, Antonio
Maria Huerta, Jose and
Ardanaz, Eva
Jose Sanchez, Maria
Dorronsoro, Miren
Ramon
Quiros, Jose
Johansson, Ingegerd
Winkvist, Anna
Sonested,
Emily
Key, Tim
Khaw, Kay-Tee
Wareham, Nicolas J. and
Peeters, Petra H. M.
Slimani, Nadia
