Τίτλος:
Single nucleotide polymorphisms in the Anti-Mullerian hormone (AMH
Ile(49)Ser) and Anti-Mullerian hormone type II receptor (AMHRII-482 A >
G) as genetic markers in assisted reproduction technology
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of the study was to evaluate whether the presence Antimullerian
hormone (AMH) and Antimullerian hormone type II receptor (AMHRII) single
nucleotide polymorphisms (SNPs) Ile(49)Ser and -482A > G respectively
are related to the assisted reproduction outcome.
A prospective cross-sectional observational study was conducted in order
to assess the distribution of AMH and AMHRII SNPs in two cohorts, one of
healthy women (N = 100) and the control group and the IVF/ICSI group (N
= 151) consisted of women undergoing IVF/ICSI treatment for infertility.
Furthermore, a prospective longitudinal observational study was
performed on the latter group to assess possible associations of these
SNPs with patients’ characteristics and controlled ovarian stimulation
(COS) and pregnancy outcome.
Among non-carriers of the AMH (Ile(49)Ser) polymorphism, basal FSH
levels were lower in those with more than two of previous IVF attempts
and fertilization rate was statistically higher in those with peak serum
E2 levels below 1500 pg/ml, whereas among non-carriers of the AMHRII
(-482 A > G) polymorphism, number of follicles was higher in those with
more than two previous IVF attempts and total dose of gonadotropins was
lower in those with peak serum E2 levels above 1500 pg/ml.
There was evidence that in specific subgroups of women undergoing
IVF/ICSI, AMH and AMHRII SNPs may be related to patients’
characteristics and controlled ovarian stimulation and pregnancy outcome
and thus may provide a means for the prediction of ovarian response in
specific subgroups of women entering an IVF/ICSI program.
Συγγραφείς:
Karagiorga, Iro
Partsinevelos, George A.
Mavrogianni, Despina
and Anagnostou, Elli
Zervomanolakis, Ioannis
Kallianidis,
Konstantinos
Drakakis, Petros
Loutradis, Dimitris
Περιοδικό:
Journal of Assisted Reproduction and Genetics
Εκδότης:
SPRINGER/PLENUM PUBLISHERS
Λέξεις-κλειδιά:
AMH; AMHRII; SNPs; ART; Genetic markers
DOI:
10.1007/s10815-014-0403-0
