Περίληψη:
Background: Vegetable and/or fruit intakes in association with
hepatocellular carcinoma (HCC) risk have been investigated in
case-control studies conducted in specific European countries and cohort
studies conducted in Asia, with inconclusive results. No multi-centre
European cohort has investigated the indicated associations.
Methods: In 486 799 men/women from the European Prospective
Investigation into Cancer and nutrition, we identified 201 HCC cases
after 11 years median follow-up. We calculated adjusted hazard ratios
(HRs) for HCC incidence for sex-specific quintiles and per 100 g d(-1)
increments of vegetable/fruit intakes.
Results: Higher vegetable intake was associated with a statistically
significant, monotonic reduction of HCC risk: HR (100 g d(-1)
increment): 0.83; 95% CI: 0.71-0.98. This association was consistent in
sensitivity analyses with no apparent heterogeneity across strata of HCC
risk factors. Fruit intake was not associated with HCC incidence: HR
(100 g d(-1) increment): 1.01; 95% CI: 0.92-1.11.
Conclusions: Vegetable, but not fruit, intake is associated with lower
HCC risk with no evidence for heterogeneity of this association in
strata of important HCC risk factors. Mechanistic studies should clarify
pathways underlying this association. Given that HCC prognosis is poor
and that vegetables are practically universally accessible, our results
may be important, especially for those at high risk for the disease.
Συγγραφείς:
Bamia, C.
Lagiou, P.
Jenab, M.
Aleksandrova, K.
Fedirko,
V.
Trichopoulos, D.
Overvad, K.
Tjonneland, A.
Olsen, A.
and Clavel-Chapelon, F.
Boutron-Ruault, M-C
Kvaskoff, M. and
Katzke, V. A.
Kuehn, T.
Boeing, H.
Noethlings, U.
Palli,
D.
Sieri, S.
Panico, S.
Tumino, R.
Naccarati, A. and
Bueno-de-Mesquita, H. B(As)
Peeters, P. H. M.
Weiderpass, E. and
Skeie, G.
Quiros, J. R.
Agudo, A.
Chirlaque, M-D and
Sanchez, M-J
Ardanaz, E.
Dorronsoro, M.
Ericson, U. and
Nilsson, L. M.
Wennberg, M.
Khaw, K-T
Wareham, N.
Key,
T. J.
Travis, R. C.
Ferrari, P.
Stepien, M. and
Duarte-Salles, T.
Norat, T.
Murphy, N.
Riboli, E. and
Trichopoulou, A.
