Τίτλος:
Impact of masking effect on subclinical carotid atherosclerosis in
normotensives and untreated masked hypertensive and hypertensive
patients
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives The masking effect (ME) is present in masked hypertensive
patients; however, both normotensive and hypertensive individuals may
show a similar phenomenon. Previous studies have shown that ME has been
associated with left ventricular hypertrophy and microalbuminuria in
treated hypertensive patients. The aim of our study was to evaluate the
association between the magnitude of systolic ME and the extent of
common carotid artery intima-media thickness (CCA-IMT) development in
normotensive individuals and untreated masked hypertensive and
hypertensive patients.
Participants and methods A total of 1154 individuals underwent 24 h
ambulatory blood pressure (BP) monitoring and carotid artery
ultrasonographic measurements. The final study population included 360
patients with systolic ME (daytime systolic BP higher than office
systolic BP). The participants were divided into three groups according
to office and daytime BP values: normotensives, masked hypertensives,
and hypertensives.
Results Masked hypertensives presented significantly higher systolic ME
(-14.6 mmHg) than their normotensive (-8.2 mmHg) and hypertensive (-9.5
mmHg) counterparts. However, systolic ME was associated significantly
with CCA-IMT only in the group of masked hypertensives (r = -0.399, P<
0.001). The multivariate linear regression analyses showed significant
and independent associations of CCA-IMT with the following factors: age
(B= 0.028, 95% confidence interval: 0.001-0.055; P= 0.044) and systolic
ME (B = -0.034, 95% confidence interval: -0.066 to -0.003; P= 0.034). A
10 mmHg decrease in systolic ME correlated to an increase of 0.034 mm in
the CCA-IMT.
Conclusion Systolic ME was associated significantly with CCA-IMT values
in masked hypertensives. Both normotensive and hypertensive participants
have failed to show similar associations. Copyright (C) 2015 Wolters
Kluwer Health, Inc. All rights reserved.
Συγγραφείς:
Manios, Efstathios
Michas, Fotios
Stamatelopoulos, Kimon and
Koroboki, Eleni
Tsouma, Iliana
Stellos, Konstantinos
Vemmos,
Konstantinos
Zakopoulos, Nikolaos
Περιοδικό:
Blood Pressure Monitoring
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
common carotid artery intima-media thickness; masked hypertension;
masking effect
DOI:
10.1097/MBP.0000000000000093
