Περίληψη:
Background: Environmental conditions early in life may imprint the
circadian system and influence response to environmental signals later
in life. We previously determined that a large springtime increase in
solar insolation at the onset location was associated with a younger age
of onset of bipolar disorder, especially with a family history of mood
disorders. This study investigated whether the hours of daylight at the
birth location affected this association.
Methods: Data collected previously at 36 collection sites from 23
countries were available for 3896 patients with bipolar I disorder, born
between latitudes of 1.4 N and 70.7 N, and 1.2 S and 413 S. Hours of
daylight variables for the birth location were added to a base model to
assess. the relation between the age of onset and solar insolation.
Results: More hours of daylight at the birth location during early life
was associated with an older age of onset, suggesting reduced
vulnerability to the future circadian challenge of the springtime
increase in solar insolation at the onset location. Addition of the
minimum of the average monthly hours of daylight during the first 3
months of life improved the base model, with a significant positive
relationship to age of onset. Coefficients for all other variables
remained stable, significant and consistent with the base model.
Conclusions: Light exposure during early life may have important
consequences for those who are susceptible to bipolar disorder,
especially at latitudes with little natural light in winter. This study
indirectly supports the concept that early life exposure to light may
affect the long term adaptability to respond to a circadian challenge
later in life. (C) 2015 Elsevier Ltd. All rights reserved.
Συγγραφείς:
Bauer, Michael
Glenn, Tasha
Alda, Martin
Andreassen, Ole A.
and Angelopoulos, Elias
Ardau, Raffaella
Baethge, Christopher
and Bauer, Rita
Baune, Bernhard T.
Bellivier, Frank and
Belmaker, Robert H.
Berk, Michael
Bjella, Thomas D.
Bossini,
Letizia
Bersudsky, Yuly
Cheung, Eric Yat Wo
Conell, Joern
and Del Zompo, Maria
Dodd, Seetal
Etain, Bruno
Fagiolini,
Andrea
Frye, Mark A.
Fountoulakis, Kostas N. and
Garneau-Fournier, Jade
Gonzalez-Pinto, Ana
Gottlieb, John F. and
Harima, Hirohiko
Hassel, Stefanie
Henry, Chantal
Iacovides,
Apostolos
Isometsa, Erkki T.
Kapczinski, Flavio
Kliwicki,
Sebastian
Koenig, Barbara
Krogh, Rikke
Kunz, Mauricio and
Lafer, Beny
Larsen, Erik R.
Lewitzka, Ute
Lopez-Jaramillo,
Carlos
MacQueen, Glenda
Manchia, Mirko
Marsh, Wendy and
Martinez-Cengotitabengo, Monica
Melle, Ingrid
Monteith, Scott
and Morken, Gunnar
Munoz, Rodrigo
Nery, Fabiano G. and
O'Donovan, Claire
Osher, Yamima
Pfennig, Andrea
Quiroz,
Danilo
Ramesar, Raj
Rasgon, Natalie
Reif, Andreas and
Ritter, Philipp
Rybakowski, Janusz K.
Sagduyu, Kemal and
Miranda-Scippa, Angela
Severus, Emanuel
Simhandl, Christian and
Stein, Dan J.
Strejilevich, Sergio
Sulaiman, Ahmad Hatim and
Suominen, Kirsi
Tagata, Hiromi
Tatebayashi, Yoshitaka and
Torrent, Carla
Vieta, Eduard
Viswanath, Biju
Wanchoo, Mihir
J.
Zetin, Mark
Whybrow, Peter C.
