Τίτλος:
Protein trafficking in colorectal carcinogenesis-targeting and bypassing
resistance to currently applied treatments
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Membrane receptors constitute novel targets during current treatment of
metastatic colorectal cancer (CRC) due to the fact that their aberrant
expression/activity favors cancer cell properties. Protein trafficking
is responsible for the correct targeting of membrane receptors to the
apical and basolateral surfaces, as well as to the adherent and tight
junctions of the cell. Impaired availability or distribution of these
receptors along the plasma membrane is not only associated with
defective cellular homeostasis and tumor progression, but also to
emerging mechanisms of resistance to CRC-targeted therapy. The present
review describes how protein trafficking facilitates invasion and
metastasis of CRC cells and focuses on receptor tyrosine kinases (RTKs)
endocytic transport, providing thoughts for surpassing RTKs-centered
mechanisms of resistance.
Συγγραφείς:
Gargalionis, Antonios N.
Karamouzis, Michalis V.
Adamopoulos,
Christos
Papavassiliou, Athanasios G.
Περιοδικό:
Journal of Carcinogenesis
Εκδότης:
Oxford University Press
DOI:
10.1093/carcin/bgv052
