Περίληψη:
Background: Geometrically-correct 3D OCT is a new imaging modality with
the potential to investigate the association of local hemodynamic
microenvironment with OCT-derived high-risk features. We aimed to
describe the methodology of 3D OCT and investigate the accuracy,
inter-and intra-observer agreement of 3D OCT in reconstructing coronary
arteries and calculating ESS, using 3D IVUS and 3D QCA as references.
Methods-Results: 35 coronary artery segments derived from 30 patients
were reconstructed in 3D space using 3D OCT. 3D OCT was validated
against 3D IVUS and 3D QCA. The agreement in artery reconstruction among
3D OCT, 3D IVUS and 3D QCA was assessed in 3-mm-long subsegments using
lumen morphometry and ESS parameters. The inter-and intra-observer
agreement of 3D OCT, 3D IVUS and 3D QCA were assessed in a
representative sample of 61 subsegments (n - 5 arteries). The data
processing times for each reconstruction methodology were also
calculated. There was a very high agreement between 3D OCT vs. 3D IVUS
and 3D OCT vs. 3D QCA in terms of total reconstructed artery length and
volume, as well as in terms of segmental morphometric and ESS metrics
with mean differences close to zero and narrow limits of agreement
(BlandeAltman analysis). 3D OCT exhibited excellent inter-and
intra-observer agreement. The analysis time with 3D OCT was
significantly lower compared to 3D IVUS.
Conclusions: Geometrically-correct 3D OCT is a feasible, accurate and
reproducible 3D reconstruction technique that can perform reliable ESS
calculations in coronary arteries. (C) 2015 Elsevier Ireland Ltd. All
rights reserved.
Συγγραφείς:
Toutouzas, Konstantinos
Chatzizisis, Yiannis S.
Riga, Maria and
Giannopoulos, Andreas
Antoniadis, Antonios P.
Tu, Shengxian and
Fujino, Yusuke
Mitsouras, Dimitrios
Doulaverakis, Charalampos
and Tsampoulatidis, Ioannis
Koutkias, Vassilis G.
Bouki,
Konstantina
Li, Yingguang
Chouvarda, Ioanna
Cheimariotis,
Grigorios
Maglaveras, Nicos
Kompatsiaris, Ioannis
Nakamura,
Sunao
Reiber, Johan H. C.
Rybicki, Frank
Karvounis,
Haralambos
Stefanadis, Christodoulos
Tousoulis, Dimitris and
Giannoglou, George D.
