Περίληψη:
Breast cancer is the most common cancer among women and prevention
strategies are needed to reduce incidence worldwide. A healthy lifestyle
index score (HLIS) was generated to investigate the joint effect of
modifiable lifestyle factors on postmenopausal breast cancer risk. The
study included 242,918 postmenopausal women from the multinational
European Prospective Investigation into Cancer and Nutrition (EPIC)
cohort, with detailed information on diet and lifestyle assessed at
baseline. The HLIS was constructed from five factors (diet, physical
activity, smoking, alcohol consumption and anthropometry) by assigning
scores of 0-4 to categories of each component, for which higher values
indicate healthier behaviours. Hazard ratios (HR) were estimated by Cox
proportional regression models. During 10.9 years of median follow-up,
7,756 incident breast cancer cases were identified. There was a 3%
lower risk of breast cancer per point increase of the HLIS. Breast
cancer risk was inversely associated with a high HLIS when fourth versus
second (reference) categories were compared [adjusted HR=0.74; 95%
confidence interval (CI): 0.66-0.83]. The fourth versus the second
category of the HLIS was associated with a lower risk for hormone
receptor double positive (adjusted HR=0.81, 95% CI: 0.67-0.98) and
hormone receptor double negative breast cancer (adjusted HR=0.60, 95%
CI: 0.40-0.90). Findings suggest having a high score on an index of
combined healthy behaviours reduces the risk of developing breast cancer
among postmenopausal women. Programmes which engage women in long term
health behaviours should be supported.
What’s new? How much does behavior really affect cancer risk? These
authors set out to measure just that. First, they created a Healthy
Lifestyle Index, which quantified five modifiable behaviors, such as
smoking and physical activity. Then, using data from the European
Prospective Investigation into Cancer and Nutrition (EPIC), they
assigned each participant a score between 0 and 4 on each of the
behaviors. It turned out that with each point added to a person’s
Healthy Lifestyle Index score, breast cancer risk fell by 3%,
suggesting that public programs to help women maintain these behaviors
could be worthwhile for cancer prevention.
Συγγραφείς:
McKenzie, Fiona
Ferrari, Pietro
Freisling, Heinz
Chajes,
Veronique
Rinaldi, Sabina
de Batlle, Jordi
Dahm, Christina
C.
Overvad, Kim
Baglietto, Laura
Dartois, Laureen and
Dossus, Laure
Lagiou, Pagona
Trichopoulos, Dimitrios and
Trichopoulou, Antonia
Krogh, Vittorio
Panico, Salvatore and
Tumino, Rosario
Rosso, Stefano
Bueno-de-Mesquita, H. B(As) and
May, Anne
Peeters, Petra H.
Weiderpass, Elisabete
Buckland,
Genevieve
Sanchez, Maria-Jose
Navarro, Carmen
Ardanaz, Eva
and Andersson, Anne
Sund, Malin
Ericson, Ulrika
Wirfalt,
Elisabet
Key, Tim J.
Travis, Ruth C.
Gunter, Marc and
Riboli, Elio
Vergnaud, Anne-Claire
Romieu, Isabelle
