Περίληψη:
Nanoparticles made of a polysiloxane matrix and surrounded by
1,4,7,10-tetraazacyclododecane-1-glutaric anhydride-4,7,10-triacetic
acid (DOTAGA)[Gd3+] and
2,2’-(7-(1-carboxy-4-((2,5-dioxopyrrolidin-1-yl)oxy)-4-oxobutyl)-1,4,7-t
riazonane-1,4-diyl)diacetic acid) NODAGA[Ga-68(3+)] have been
synthesized for positron emission tomography/magnetic resonance
(PET/MRI) dual imaging. Characterizations were carried out in order to
determine the nature of the ligands available for radiolabelling and to
quantify them. High radiolabelling purity (>95%) after Ga-68 labelling
was obtained. The MR and PET images demonstrate the possibility of using
the nanoparticles for a combined PET/MR imaging scanner. The images show
fast renal elimination of the nanoparticles after intravenous
injection.Copyright (C) 2014 John Wiley & Sons, Ltd.
Συγγραφείς:
Truillet, Charles
Bouziotis, Penelope
Tsoukalas, Charalambos and
Brugiere, Jeremy
Martini, Matteo
Sancey, Lucie
Brichart,
Thomas
Denat, Franck
Boschetti, Frederic
Darbost, Ulrich and
Bonnamour, Isabelle
Stellas, Dimitris
Anagnostopoulos,
Constantinos D.
Koutoulidis, Vassilis
Moulopoulos, Lia A. and
Perriat, Pascal
Lux, Francois
Tillement, Olivier