Περίληψη:
Background: Early diagnosis and treatment of neonatal infection is
important to prevent morbidity and mortality. The gastrointestinal
tract-derived hormones ghrelin and peptide YY (PYY), which participate
in the regulation of food intake and energy balance, may also play roles
in the inflammatory response. Their involvement in neonatal infection is
not known.
Methods: Plasma ghrelin and PYY(3-36) levels were serially measured (by
ELISA) on Days 0, 1, 2, 3 and 7 following admission in 36-term neonates
with febrile infection (22 of them were septic) and once in 20 healthy
term neonates of similar postnatal age and gender distribution, as
controls. Associations of ghrelin and PYY(3-36) levels with clinical and
laboratory parameters, including anthropometrics, fever, leukocyte and
platelet counts, serum glucose, C-reactive protein (CRP) and serum
amyloid A levels, were assessed.
Results: Plasma ghrelin levels were significantly higher in infected
neonates than in controls at each study day (p=0.009), whereas PYY(3-36)
levels did not differ significantly between patients and controls at any
day. In infected neonates, ghrelin levels on admission correlated
negatively with serum glucose levels (p=0.003), whereas fever change
during the course of infection was significantly associated with change
of ghrelin levels (p=0.01). Receiver operating characteristic analysis
of ghrelin levels resulted in significant areas under the curve (AUC)
for detecting infected neonates on admission (AUC=0.728, p=0.005).
Conclusions: Circulating ghrelin, but not PYY(3-36), levels are
increased in neonates with infection, possibly reflecting and/or
participating in the inflammatory process.
Συγγραφείς:
Siahanidou, Tania
Margeli, Alexandra
Tsirogianni, Chrysanthi and
Hantzi, Eugenia
Papassotiriou, Ioannis
Chrousos, George
