Ερευνητικό υλικό ΕΚΠΑ

Genome-Wide Association Study of Prostate Cancer-Specific Survival

Αγγλικά

Background: Unnecessary intervention and overtreatment of indolent
disease are common challenges in clinical management of prostate cancer.
Improved tools to distinguish lethal from indolent disease are critical.
Methods: We performed a genome-wide survival analysis of cause-specific
death in 24,023 prostate cancer patients (3,513 disease-specific deaths)
from the PRACTICAL and BPC3 consortia. Top findings were assessed for
replication in a Norwegian cohort (CONOR).
Results: We observed no significant association between genetic variants
and prostate cancer survival.
Conclusions: Common genetic variants with large impact on prostate
cancer survival were not observed in this study.
Impact: Future studies should be designed for identification of rare
variants with large effect sizes or common variants with small effect
sizes. (C) 2015 AACR.

2015

Szulkin, Robert
Karlsson, Robert
Whitington, Thomas
Aly,
Markus
Gronberg, Henrik
Eeles, Rosalind A.
Easton, Douglas
F.
Kote-Jarai, Zsofia
Al Olama, Ali Amin
Benlloch, Sara and
Muir, Kenneth
Giles, Graham G.
Southey, Melissa C. and
FitzGerald, Liesel M.
Henderson, Brian E.
Schumacher, Fredrick
R.
Haiman, Christopher A.
Sipeky, Csilla
Tammela, Teuvo L.
J.
Nordestgaard, Borge G.
Key, Timothy J.
Travis, Ruth C.
and Neal, David E.
Donovan, Jenny L.
Hamdy, Freddie C. and
Pharoah, Paul D. P.
Pashayan, Nora
Khaw, Kay-Tee
Stanford,
Janet L.
Thibodeau, Stephen N.
McDonnell, Shannon K.
Schaid,
Daniel J.
Maier, Christiane
Vogel, Walther
Luedeke, Manuel
and Herkommer, Kathleen
Kibel, Adam S.
Cybulski, Cezary and
Lubinski, Jan
Kluzniak, Wojciech
Cannon-Albright, Lisa and
Brenner, Hermann
Herrmann, Volker
Holleczek, Bernd
Park,
Jong Y.
Sellers, Thomas A.
Lim, Hui-Yi
Slavov, Chavdar and
Kaneva, Radka P.
Mitev, Vanio I.
Spurdle, Amanda
Teixeira,
Manuel R.
Paulo, Paula
Maia, Sofia
Pandha, Hardev and
Michael, Agnieszka
Kierzek, Andrzej
Batra, Jyotsna
Clements,
Judith A.
Albanes, Demetrius
Andriole, Gerald L.
Berndt,
Sonja I.
Chanock, Stephen
Gapstur, Susan M.
Giovannucci,
Edward L.
Hunter, David J.
Kraft, Peter
Le Marchand, Loic
and Ma, Jing
Mondul, Alison M.
Penney, Kathryn L.
Stampfer,
Meir J.
Stevens, Victoria L.
Weinstein, Stephanie J. and
Trichopoulou, Antonia
Bueno-de-Mesquita, Bas H.
Tjonneland, Anne
and Cox, David G.
Maehle, Lovise
Schleutker, Johanna and
Lindstroem, Sara
Wiklund, Fredrik
PRACTICAL Consortium and
Australian Prostate Canc BioResour
BPC3 Consortium

Cancer Epidemiology, Biomarkers & Prevention

AMER ASSOC CANCER RESEARCH

24

11

1796-1800

https://doi.org/10.1158/1055-9965.EPI-15-0543

10.1158/1055-9965.EPI-15-0543

https://pergamos.lib.uoa.gr/uoa/dl/object/3167570