Περίληψη:
Background: Higher coffee intake has been purportedly related to a lower
risk of liver cancer. However, it remains unclear whether this
association may be accounted for by specific biological mechanisms.
Objective: We aimed to evaluate the potential mediating roles of
inflammatory, metabolic, liver injury, and iron metabolism biomarkers on
the association between coffee intake and the primary form of liver
cancer-hepatocellular carcinoma (HCC).
Design: We conducted a prospective nested case-control study within the
European Prospective Investigation into Cancer and Nutrition among 125
incident HCC cases matched to 250 controls using an incidence-density
sampling procedure. The association of coffee intake with HCC risk was
evaluated by using multivariable-adjusted conditional logistic
regression that accounted for smoking, alcohol consumption, hepatitis
infection, and other established liver cancer risk factors. The
mediating effects of 21 biomarkers were evaluated on the basis of
percentage changes and associated 95% CIs in the estimated regression
coefficients of models with and without adjustment for biomarkers
individually and in combination.
Results: The multivariable-adjusted RR of having >= 4 cups (600mL)
coffee/d compared with <2 cups (300 mL)/d was 0.25 (95% CI: 0.11, 0.62;
P-trend = 0.006). A statistically significant attenuation of the
association between coffee intake and HCC risk and thereby suspected
mediation was confirmed for the inflammatory biomarker IL-6 and for the
biomarkers of hepatocellular injury glutamate dehydrogenase, alanine
aminotransferase, aspartate aminotransferase (AST),
gamma-glutamyltransferase (GGT), and total bilirubin, which-in
combination-attenuated the regression coefficients by 72% (95% CI:
7%, 239%). Of the investigated biomarkers, IL-6, AST, and GGT produced
the highest change in the regression coefficients: 40%, 56%, and 60%,
respectively.
Conclusion: These data suggest that the inverse association of coffee
intake with HCC risk was partly accounted for by biomarkers of
inflammation and hepatocellular injury.
Συγγραφείς:
Aleksandrova, Krasimira
Bamia, Christina
Drogan, Dagmar and
Lagiou, Pagona
Trichopoulou, Antonia
Jenab, Mazda
Fedirko,
Veronika
Romieu, Isabelle
Bueno-de-Mesquita, H. Bas
Pischon,
Tobias
Tsilidis, Kostas
Overvad, Kim
Tjonneland, Anne and
Bouton-Ruault, Marie-Christine
Dossus, Laure
Racine, Antoine and
Kaaks, Rudolf
Kuehn, Tilman
Tsironis, Christos
Papatesta,
Eleni-Maria
Saitakis, George
Palli, Domenico
Panico,
Salvatore
Grioni, Sara
Tumino, Rosario
Vineis, Paolo and
Peeters, Petra H.
Weiderpass, Elisabete
Lukic, Marko and
Braaten, Tonje
Ramon Quiros, J.
Lujan-Barroso, Leila and
Sanchez, Mara-Jose
Chilarque, Maria-Dolores
Ardanas, Eva and
Dorronsoro, Miren
Nilsson, Lena Maria
Sund, Malin
Wallstrom,
Peter
Ohlsson, Bodil
Bradbury, Kathryn E.
Khaw, Kay-Tee and
Wareham, Nick
Stepien, Magdalena
Duarte-Salles, Talita
Assi,
Nada
Murphy, Neil
Gunter, Marc J.
Riboli, Elio
Boeing,
Heiner
Trichopoulos, Dimitrios
