Περίληψη:
Previously, a lower risk of colorectal cancer was observed with fruit
and vegetable consumption in the European Prospective Investigation into
Cancer and Nutrition within a follow-up period of 9 years which was not
fully supported by a recent meta-analysis. Therefore, we were interested
in the relation with extended follow-up, also focusing on single
subtypes and a variety of intake of fruit and vegetables. Fruit and
vegetable consumption was assessed at baseline. After an average of 13
years of follow-up, 3,370 participants were diagnosed with colon or
rectal cancer. Diet diversity scores were constructed to quantify
variety in fruit and vegetable consumption. A lower risk of colon cancer
was observed with higher self-reported consumption of fruit and
vegetable combined (HR Q4 vs. Q1 0.87, 95% CI 0.75-1.01, p for trend
0.02), but no consistent association was observed for separate
consumption of fruits and vegetables. No associations with risk of
rectal cancer were observed. The few observed associations for some
fruit and vegetable subtypes with colon cancer risk may have been due to
chance. Variety in consumption of fruits and vegetables was not
associated with a lower risk of colon or rectal cancer. Although a lower
risk of colon cancer is suggested with high consumption of fruit and
vegetables, this study does not support a clear inverse association
between fruit and vegetable consumption and colon or rectal cancer
beyond a follow-up of more than 10 years. Attenuation of the risk
estimates from dietary changes over time cannot be excluded, but appears
unlikely.
Συγγραφείς:
Leenders, Max
Siersema, Peter D.
Overvad, Kim
Tjonneland,
Anne
Olsen, Anja
Boutron-Ruault, Marie-Christine
Bastide,
Nadia
Fagherazzi, Guy
Katzke, Verena
Kuehn, Tilman and
Boeing, Heiner
Aleksandrova, Krasimira
Trichopoulou, Antonia and
Lagiou, Pagona
Klinaki, Eleni
Masala, Giovanna
Grioni, Sara
and De Magistris, Maria Santucci
Tumino, Rosario
Ricceri, Fulvio
and Peeters, Petra H. M.
Lund, Eiliv
Skeie, Guri
Weiderpass,
Elisabete
Ramon Quiros, J.
Agudo, Antonio
Sanchez,
Maria-Jose
Dorronsoro, Miren
Navarro, Carmen
Ardanaz, Eva
and Ohlsson, Bodil
Jirstroem, Karin
Van Guelpen, Bethany and
Wennberg, Maria
Khaw, Kay-Tee
Wareham, Nick
Key, Timothy J.
and Romieu, Isabelle
Huybrechts, Inge
Cross, Amanda J. and
Murphy, Neil
Riboli, Elio
Bueno-de-Mesquita, H. B(As)
