Τίτλος:
TSH-secreting pituitary adenomas treated by gamma knife radiosurgery:
our case experience and a review of the literature
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
A 43-year-old woman, previously misdiagnosed as having primary
hyperthyroidism and treated with antithyroid drugs, presented to us with
overt hyperthyroidism, high levels of thyroid hormones and elevated
thyroid-stimulating hormone (TSH). Magnetic resonance imaging (MRI)
revealed a pituitary microadenoma extending suprasellarly. The patient
responded favorably to initial treatment with somatostatin analogs for 2
years but due to the escape phenomenon, TSH levels escalated and
hyperthyroidism relapsed. Transsphenoidal adenomectomy was applied but
recurrence was again observed due to incomplete tumor removal. Gamma
knife radiosurgery was finally employed 5.5 years ago, resulting in
complete disease remission without evidence of long-term complications
to date. Thyrotropin-secreting adenomas (TSHomas) are rare with an
estimated prevalence of about one case per million. We retrieved from
the literature 14 cases of TSHomas treated by gamma knife radiosurgery
and compared the outcomes. Our results demonstrate the efficacy and
safety of gamma knife radiosurgery for achieving remission in most of
the cases, suggesting validation of this technique as an effective
treatment option for the management of recurrent TSHomas.
Συγγραφείς:
Mouslech, Zadalla
Somali, Maria
Sakali, Anastasia Konstantina
and Savopoulos, Christos
Mastorakos, George
Hatzitolios,
Apostolos I.
Περιοδικό:
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
Εκδότης:
SPRINGER INTERNATIONAL PUBLISHING AG
Λέξεις-κλειδιά:
Thyrotropin-secreting pituitary adenoma; Hyperthyroidism; Long-acting
somatostatin analogs; Transsphenoidal adenomectomy; Gamma knife
radiosurgery; Long-term remission
