Τίτλος:
The Tree of Sirtuins and the Garden of Cardiovascular Youth
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Sirtuins (SIRTs) are a class of nicotine adenine dinucleotide
(NAD+)-dependent proteins which participate in numerous molecular
pathways involved in various age-related human diseases, such as type II
diabetes, cardiovascular (CV) diseases and cancer. They have a major
role in apoptosis, inflammation, oxidative stress and metabolism
regulation, traits that have a great impact on CV physiology and
pathology. Their unique profile of NAD+ energy dependency makes them an
appealing target for human intervention in cellular and metabolic
processes. This review focuses on the recent advances of SIRTs research
aiming to shed light on the emerging roles of SIRTs in the
pathophysiology of CV and metabolic diseases.
Συγγραφείς:
Katsi, Vasiliki K.
Pavlidis, Antonios N.
Liakos, Charalampos I.
and Marketou, Maria E.
Raftopoulos, Leonidas G.
Alexopoulos,
Nikolaos A.
Makris, Thomas K.
Nihoyannopoulos, Petros and
Tousoulis, Dimitris
Kallikazaros, Ioannis E.
Περιοδικό:
Current Vascular Pharmacology
Εκδότης:
BENTHAM SCIENCE PUBL LTD
Λέξεις-κλειδιά:
Sirtuins; aging; cardiovascular diseases; cancer; apoptosis; oxidative
stress
DOI:
10.2174/1570161113666150916093902
